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Rapid Commun."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Polyethylene glycol (PEG) is widely used to provide a stealth effect in various therapeutic applications. However, an increased occurrence of anti\u2010PEG antibodies in patients can lead to immunological side effects and accelerated blood clearance, reducing the efficiency of PEG\u2010based delivery vectors. One of these PEG\u2010containing vectors is lipid nanoparticles (LNPs), which effectively deliver nucleic acids. Their high potential for treating a great number of diseases in the future was already showcased in the mRNA vaccines developed during the COVID\u201019 pandemic. Thus, the aim of our study was to formulate LNP systems utilizing linear polyglycerol (lPG) as an alternative stealth polymer to avoid anti\u2010PEG antibodies while enabling mRNA delivery. 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