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Rapid Commun."],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Reliable classification of polymer\u2013solvent compatibility is essential for solution formulation and materials discovery. Applying machine learning (ML) and artificial intelligence to this task is of growing interest in polymer science, but the effectiveness of such models depends on the quality\/nature of the training data. This study evaluates how experimental data fidelity, as set by the experimental method, influences ML model performance by comparing classifiers trained on two experimental datasets: one generated from turbidity\u2010based measurements using a Crystal16 parallel crystallizer as a high\u2010fidelity source and another derived from visual solubility inspection as a low\u2010fidelity dataset. Both datasets were encoded using one\u2010hot encoding for polymers and Morgan fingerprints for solvents and modeled using XGBoost classifiers to predict solubility labels as soluble, insoluble, and partially soluble. Confusion matrices showed that models trained on high\u2010fidelity data better captured partially soluble behavior and more clearly distinguished between classes, highlighting the advantage of quantitative measurements over subjective classification. We also found that adding temperature as a feature improved prediction accuracy for the low\u2010fidelity dataset\u2014a key consideration for literature\u2010derived data, which often lacks this information. These findings underscore the importance of experimental rigor and completeness when developing generalizable ML\u2010based tools for polymer solubility prediction.<\/jats:p>","DOI":"10.1002\/marc.202500454","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T10:49:34Z","timestamp":1753699774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of High Fidelity Vs. 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