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Curing under flood UV irradiation yielded a rigid thermoset (E\u2032 \u223c2.5\u00a0GPa at 25\u00b0C) with a glass transition temperature of about 50\u00b0C. Using TPP, we fabricated various microscale needles (100 \u00d7 100 \u00d7 400 \u00b5m, 2 \u00b5m resolution) from this resin, enabling direct printing of intrinsically therapeutic microstructures without post\u2010processing drug loading. The cured polymer acts as both a structural matrix and a hydrolytically degradable polyprodrug, releasing estradiol through cleavage of ester bonds. By combining covalent drug\u2010polymer integration with high\u2010resolution 3D printing, this work establishes a platform for personalized transdermal drug delivery devices with spatially controlled release profiles determined by microstructure design and polymer degradation kinetics.<\/jats:p>","DOI":"10.1002\/marc.202500467","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:41:42Z","timestamp":1765208502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polymerized Pro\u2010Estrogen Microneedles via Two Photon Polymerization"],"prefix":"10.1002","volume":"47","author":[{"given":"Yang","family":"Lou","sequence":"first","affiliation":[{"name":"Materials Science &amp; Engineering Rensselaer Polytechnic Institute  Troy New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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