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Rapid Commun."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antimicrobial resistance is a critical global healthcare issue that urgently needs the development of new antimicrobial agents. Herein, we developed new and discrete cationic amphipathic cyclic peptidomimetics as potential antimicrobial agents to combat multidrug\u2010resistant bacteria. These cyclic oligomers of different alkyl chain lengths are easy to obtain via carbodiimide\u2010mediated condensation reaction and using aza\u2010crown ether as the core reactant. The antimicrobial activity, membrane perturbation effects, and toxicity of the compounds are strongly dependent on the hydrophobic alkyl chain length, as longer lipid chains result in greater antimicrobial potency and membrane disruption but also poorer biocompatibility. For example, cyclic compound bearing 16\u2010carbon chain (\n                    <jats:bold>CYPEP\u2010C16<\/jats:bold>\n                    ) has the best bacteriostatic activity against several bacteria strains with minimum inhibitory concentrations of 16\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    but is also toxic, though this can potentially be remedied with different strategies. Critically, the cyclic compounds bearing polyoxazoline\u2010esque backbone can withstand proteolytic degradation and maintain their antimicrobial potency, unlike other polyamide systems. This study thus highlights the potential of these cyclic peptidomimetics as promising new antimicrobial agents.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500569","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:04:28Z","timestamp":1758564268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antimicrobial Cyclic Peptidomimetics"],"prefix":"10.1002","volume":"47","author":[{"given":"Hao","family":"Luo","sequence":"first","affiliation":[{"name":"School of Chemical Engineering University of New South Wales (UNSW)  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5151-5045","authenticated-orcid":false,"given":"Edgar H. 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