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Rapid Commun."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The ability to combine biodegradability with responsive units by radical ring\u2010opening polymerization (RROP) is the ideal setup for a modern drug delivery system. Since the required polymers were recently unlocked by RROP copolymerization between different cyclic ketene acetals (CKAs), we herein prepared a series of polyester copolymers derived from an amine\u2010bearing CKA 6\u2010(\n                    <jats:italic>iso<\/jats:italic>\n                    \u2010propyl)\u20102\u2010methylene\u20101,3,6\u2010dioxazocane (\n                    <jats:italic>\n                      <jats:sup>i<\/jats:sup>\n                    <\/jats:italic>\n                    Pr\u2010MAC) and 2\u2010methylene\u20101,3,6\u2010trioxocane (MTC). Functional nanoparticles with tunable sizes and extremely narrow size distributions could be achieved from these copolymers. Comprehensive studies showed that the resulting nanoparticles exhibited tuneable pH\u2010transition points from 6.3 to 7.1 as the\n                    <jats:italic>\n                      <jats:sup>i<\/jats:sup>\n                    <\/jats:italic>\n                    Pr\u2010MAC content increased from 10 to 40 mol%, enabling precise pH\u2010triggered control release at varying pH levels. Furthermore, this work demonstrates the potential of these pH\u2010sensitive polyesters as an alternative to traditional polycations, exploring their biocompatibility and gene delivery capability, which suggests a new application prospect for CKA\u2010derived functional polyesters.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500722","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:36:31Z","timestamp":1760643391000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Degradable Nanocarriers Capable of Gene Delivery Derived from pH\u2010Responsive Polyester: RROP Copolymerization Between Cyclic Ketene Acetals"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8156-5067","authenticated-orcid":false,"given":"Yiyi","family":"Deng","sequence":"first","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Polymerforschung Dresden e.V.  Dresden Germany"},{"name":"Fakult\u00e4t Chemie und Lebensmittelchemie Technische Universit\u00e4t Dresden  Dresden Germany"},{"name":"Universit\u00e9 Paris\u2010Saclay CNRS Institut Galien Paris\u2010Saclay  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Debbeler","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-2293","authenticated-orcid":false,"given":"Anja","family":"Traeger","sequence":"additional","affiliation":[{"name":"Laboratory of Organic and Macromolecular Chemistry Friedrich Schiller University Jena  Jena Germany"},{"name":"Jena Center for Soft Matter (JCSM) Friedrich Schiller University Jena  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-982X","authenticated-orcid":false,"given":"Jens","family":"Gaitzsch","sequence":"additional","affiliation":[{"name":"Leibniz\u2010Institut F\u00fcr Polymerforschung Dresden e.V.  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