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Rapid Commun."],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polyethylene glycol (PEG) plays a central role in nanomedicine, providing essential properties such as the stealth effect. However, the emergence of anti\u2010PEG antibodies (APAs) increasingly undermines these benefits, raising concerns about safety and efficiency. This creates an urgent need for PEG alternatives. Randomized PEG (rPEG) represents a conceptually new strategy that preserves the PEG\u2010like structure and performance while markedly reducing antigenicity. In this work, rPEG is employed as a non\u2010antigenic A\u2010block in ABA\u2010type polymeric micelles (PMs). To enhance drug loading capacity beyond conventional PMs, the hydrophobic middle block is composed of poly(2\u2010phenyl\u20102\u2010oxazine) (PPheOzi). rPEG is synthesized by anionic ring\u2010opening polymerization, PPheOzi by cationic ring\u2010opening polymerization, and the combined rPEG\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010PPheOzi\u2010\n                    <jats:italic>b<\/jats:italic>\n                    \u2010rPEG triblock copolymers are linked via copper\u2010catalyzed azide\u2010alkyne cycloaddition. The formulations exhibit a distinct correlation between the solubilization of Efavirenz and the systematically varied rPEG composition, ranging from outstanding to moderate micelle drug loading capacities. A fundamental preclinical safety profile was established through investigations in murine fibroblasts and human peripheral blood mononuclear cells (PBMCs). Competitive enzyme\u2010linked immunosorbent assays (ELISA) revealed a pronounced reduction in APA affinity in comparison to PEG. Taken together, the synergistic combination of rPEG and PPheOzi establishes a non\u2010antigenic micellar platform capable of achieving high drug loadings.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500781","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T19:48:31Z","timestamp":1766605711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Non\u2010Antigenic Randomized Polyethylene Glycol\/Poly(2\u2010Phenyl\u20102\u2010Oxazine)\u2010Based Drug Delivery Platform"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1206-099X","authenticated-orcid":false,"given":"Julian","family":"Schmidt","sequence":"first","affiliation":[{"name":"Department of Chemistry Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6963-1628","authenticated-orcid":false,"given":"Anna\u2010Lena","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Soft Matter Chemistry Department of Chemistry and Helsinki Institute of Sustainability Science Faculty of Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8518-0518","authenticated-orcid":false,"given":"Florian T.","family":"Kaps","sequence":"additional","affiliation":[{"name":"Soft Matter Chemistry Department of Chemistry and Helsinki Institute of Sustainability Science Faculty of Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8477-7892","authenticated-orcid":false,"given":"Laura J.","family":"Rosenberger","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Bros","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-3103","authenticated-orcid":false,"given":"Holger","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Chemistry Johannes Gutenberg University Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5567-7404","authenticated-orcid":false,"given":"Robert","family":"Luxenhofer","sequence":"additional","affiliation":[{"name":"Soft Matter Chemistry Department of Chemistry and Helsinki Institute of Sustainability Science Faculty of Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10600"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.6"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1033"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540600814402"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40292-4"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40291-2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja504390x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2015.330"},{"key":"e_1_2_10_10_1","first-page":"97","article-title":"Effect of the Protein Corona on Nanoparticles for Modulating Cytotoxicity and Immunotoxicity","volume":"10","author":"Lee Y. 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