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Our results show that antibody\u2010functionalized terbium coordination polymer particles efficiently captured PLAP\u2010positive EVs, which could be gently released, preserving their integrity for downstream analysis. Transmission electron microscopy confirms the recovery of intact EVs, while Quantitative Reverse Transcription Polymerase Chain Reaction analysis is performed for the detection of KISS1 mRNA, a potential biomarker for preeclampsia. This method offers a gentle, efficient, and specific approach for EV isolation, providing a valuable tool for studying placental dysfunction and advancing biomarker analysis in preeclampsia.<\/jats:p>","DOI":"10.1002\/marc.202500785","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:41:00Z","timestamp":1765208460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Detection of Placental Extracellular Vesicle Biomarker with Terbium Coordination Polymer"],"prefix":"10.1002","volume":"47","author":[{"given":"Cong Minh","family":"Nguyen","sequence":"first","affiliation":[{"name":"School of Environment and Science Griffith University  Nathan Australia"},{"name":"Queensland Quantum and Advanced Technologies Research Institute Griffith University  Nathan 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