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Rapid Commun."],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polymer lipids (PLs) are an essential component for the stability of lipid nanoparticles (LNPs) for gene delivery. Poly(ethylene glycol) (PEG)\u2010based lipids are the current gold standard. However, they are suspected to be responsible for rare adverse reactions to the LNP\u2010based COVID\u201019 vaccines. Therefore, alternative PLs are being intensively investigated. A particularly promising alternative are poly(sarcosine) (PSar)\u2010based lipids. However, one significant bottleneck of pSar\u2010based biomaterials is the synthesis of the monomer sarcosine\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010carboxyanhydride (Sar\u2010NCA). Current methods rely on highly toxic di\u2010 or triphosgene to obtain the monomer directly from the amino acid sarcosine. Herein, we present a phosgene\u2010free, CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based route to Sar\u2010NCA in gram scale and excellent purity, suitable for the subsequent living polymerization to pSar. Furthermore, we used the obtained pSar for the synthesis of pSar\u00a0lipids suitable for LNP preparation. Due to its low toxicity and simplicity, the CO\n                    <jats:sub>2<\/jats:sub>\n                    \u2010based Sar\u2010NCA synthesis has great potential to become an attractive alternative to current monomer synthesis pathways.\n                  <\/jats:p>","DOI":"10.1002\/marc.202500841","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T08:28:12Z","timestamp":1768206492000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Poly(sarcosine) Lipid Synthesis From CO\n                    <sub>2<\/sub>\n                    \u2010Based Sarcosine\u2010\n                    <i>N<\/i>\n                    \u2010Carboxyanhydride"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8518-0518","authenticated-orcid":false,"given":"Florian T.","family":"Kaps","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8289-3014","authenticated-orcid":false,"given":"Leon","family":"Quellmalz","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Helsinki  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6555-8869","authenticated-orcid":false,"given":"Annika D. 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