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Rapid Commun."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Precise spatial confinement of enzymes at oil\u2010water interfaces offers an elegant strategy to enhance biphasic catalysis yet achieving robust and recyclable interfacial assemblies remains challenging. Here, we introduce an amphiphilic polymeric Janus particle platform that enables lipases to preferentially localize at interfaces, thereby achieving efficient Pickering interfacial catalysis (PIC). Crosslinked poly(hydroxypropyl methacrylate) colloids bearing surface carboxylic acid groups were synthesized via RAFT\u2010mediated heterogeneous copolymerization and further transformed into snowman\u2010shaped Janus particles through seeded emulsion polymerization. The resulting amphiphilic Janus colloids possess distinct hydrophilic\u2010hydrophobic domains that facilitate both enzyme anchoring and emulsion stabilization. Candida rugosa lipase (CRL) immobilized on these particles exhibited strong interfacial activity, achieving enhanced catalytic efficiency, thermal stability, and recyclability compared to free CRL. The present work suggests that enzyme immobilization on Janus colloids is a promising approach to advance next\u2010generation PIC.<\/jats:p>","DOI":"10.1002\/marc.202500869","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T14:50:24Z","timestamp":1768747824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Polymeric Janus Colloids Enable a New Paradigm of Spatially Confined Enzymes in Pickering Interfacial Catalysis"],"prefix":"10.1002","author":[{"given":"Siga","family":"Jia","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zishan","family":"Tu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, 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