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Rapid Commun."],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lubrication is essential for maintaining joint health and enabling smooth articulation. In healthy joints, natural lubricants such as proteoglycans endow articular cartilage with an exceptionally low coefficient of friction. Notably, proteoglycans possess a characteristic bottle\u2010brush architecture that generates robust hydration layers at the cartilage surface, thereby facilitating effective lubrication. In osteoarthritis (OA), degradation of extracellular matrix components, depletion of proteoglycans, and increased friction and wear at inflamed joint interfaces collectively accelerate disease progression. Therefore, restoring joint lubrication has emerged as a promising strategy to reduce friction\u2010induced damage and delay OA progression. In recent years, extensive efforts have been devoted to developing biomimetic lubricants, particularly proteoglycan\u2010mimetic polymer brushes inspired by natural proteoglycan architectures. These systems are designed to replicate the bottle\u2010brush architecture and hydration lubrication mechanism of native proteoglycans. In this review, we summarize the fundamental lubrication mechanisms of articular cartilage, with emphasis on boundary and hydration lubrication mediated by proteoglycans, and discuss the design principles and representative material systems of proteoglycan\u2010mimetic polymer brushes. By linking native lubrication mechanisms with biomimetic brush design and translational considerations, this review highlights proteoglycan\u2010inspired polymer brushes as promising disease\u2010modifying candidates for OA treatment.<\/jats:p>","DOI":"10.1002\/marc.70358","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:17:15Z","timestamp":1783685835000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proteoglycan\u2010Mimetic Bottle\u2010Brush Polymer Brushes for Osteoarthritis Therapy: Lubrication Enhancement and Multifunctional Disease Modulation"],"prefix":"10.1002","volume":"47","author":[{"given":"Fei","family":"Chen","sequence":"first","affiliation":[{"name":"Biomedical Sciences College Shandong Medicinal Biotechnology Centre Shandong First Medical University &amp; Shandong Academy of Medical Sciences  Jinan Shandong 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