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Rapid Commun."],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This work investigates the synthesis of polypeptoid nanoparticles through Ugi\u2010mediated polymerization\u2010induced self\u2010assembly (U\u2010PISA), combining aqueous Ugi four\u2010component polycondensation with PEG\u2010based stabilization. Polypeptoid nano\u2010objects were produced directly from amino acid\u2010derived building blocks via a one\u2010pot process under mild, open\u2010air conditions. The effects of PEG molar mass and feed composition on particle formation and morphology were systematically examined, providing access to tunable spherical and worm\u2010like nanostructures. The in situ formation of amphiphilic PEG\u2010polypeptoid species suggests that nanoparticle formation proceeds through a PISA\u2010like mechanism. However, the step\u2010growth nature of the Ugi polycondensation implies that both PEG\u2010functionalized and unconjugated polypeptoid chains may participate in nanoparticle assembly and stabilization. These results demonstrate that multicomponent polymerizations, such as Ugi polymerization, can be integrated into a PISA strategy, offering a simple route to polypeptoid nanoparticles with tunable morphologies and potential biomedical applications.<\/jats:p>","DOI":"10.1002\/marc.70389","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:30:19Z","timestamp":1787927419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring a Ugi\u2010Mediated Polymerization\u2010Induced Self\u2010Assembly Approach to Peptoid Particles"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-9984","authenticated-orcid":false,"given":"Thi Phuong Thu","family":"Nguyen","sequence":"first","affiliation":[{"name":"Univ Paris Est Creteil, CNRS, Institut de Chimie et des Mat\u00e9riaux Paris\u2010Est(ICMPE) UMR 7182  Thiais France"},{"name":"Laboratoire De Chimie de La Mati\u00e8re Condens\u00e9e De Paris UMR 7574 Sorbonne Universit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0868-2847","authenticated-orcid":false,"given":"Maria Cristina","family":"Molaro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao\u2010Ning","family":"Tien","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, CNRS, Institut de Chimie et des Mat\u00e9riaux Paris\u2010Est(ICMPE) UMR 7182  Thiais France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8441-2044","authenticated-orcid":false,"given":"Lei","family":"Lei","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, CNRS, Institut de Chimie et des Mat\u00e9riaux Paris\u2010Est(ICMPE) UMR 7182  Thiais 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2013-4893","authenticated-orcid":false,"given":"Federica","family":"Sodano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy School of Medicine University of Naples Federico II  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7909-7006","authenticated-orcid":false,"given":"Antoine","family":"Debuigne","sequence":"additional","affiliation":[{"name":"Center for Education and Research on Macromolecules (CERM) CESAM Research Unit University of Liege (ULiege)  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1192-5354","authenticated-orcid":false,"given":"Benoit","family":"Couturaud","sequence":"additional","affiliation":[{"name":"Univ Paris Est Creteil, CNRS, Institut de Chimie et des Mat\u00e9riaux Paris\u2010Est(ICMPE) UMR 7182  Thiais 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