{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:07:45Z","timestamp":1789999665693,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Macromol. Rapid Commun."],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Catechol grafted macromolecules have attributes that overlap what's needed within non\u2010toxic bioadhesives. However, decades of research have failed to make commercial progress as a general tissue adhesive. The major impediments include reliance on harmful crosslinking additives, long\u2010term shelf\u2010stability, and variability in preparation (e.g. two component mixing). This can arguably be assigned to the over\u2010reliance on just one catechol crosslinker based on L\u2010dopamine. Herein, we evaluate catechol scaffolds and oxidation processes that side\u2010step these limitations and provide one\u2010component (1C) bioadhesive designs. These 1C designs hypothesize activation via surface contact and oxygen exposure. The branched polyethylenimine (PEI) dendrimer serves as a model macromolecule, easily grafted via Schiff\u2010base click chemistry. One of the optimized formulations, PEI\u2010(5\u2010OMe\u20103,4\u2010DBA)\n                    <jats:sub>20<\/jats:sub>\n                    , in which 20% of the primary amine groups of PEI are grafted with 5\u2010methoxy\u20103,4\u2010dihydroxybenzaldehyde (5\u2010OMe\u20103,4\u2010DBA) through Schiff\u2010base linkages, initiates crosslinking immediately after air\/O\n                    <jats:sub>2<\/jats:sub>\n                    exposure, but remains stable in anaerobic environments. Structural evaluation confirms PEI\u2010(5\u2010OMe\u20103,4\u2010DBA)\n                    <jats:sub>20<\/jats:sub>\n                    undergoes spontaneous conversion to quinones, supported by aromatic CH integration (\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR) and first order decay of 5\u2010OMe catechol Schiff\u2010base (UV\u2013vis). Gelation time occurs in \u2329 1 min with shear strengths of 26 kPa on wetted collagen substrates.\n                  <\/jats:p>","DOI":"10.1002\/marc.70391","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T10:21:42Z","timestamp":1786011702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oxygen Initiated Crosslinking of Electronically Optimized Catechols"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5406-0365","authenticated-orcid":false,"given":"Animesh","family":"Ghosh","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering (MSE) Division of Materials Technology Nanyang Technological University (NTU)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki X.","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering (MSE) Division of Materials Technology Nanyang Technological University (NTU)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Kozlowski","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering (MSE) Division of Materials Technology Nanyang Technological University (NTU)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4296-5279","authenticated-orcid":false,"given":"Darien","family":"Kwek","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering (MSE) Division of Materials Technology Nanyang Technological University (NTU)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8596-9619","authenticated-orcid":false,"given":"Terry W. J.","family":"Steele","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering (MSE) Division of Materials Technology Nanyang Technological University (NTU)  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00285E"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201500006"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2021.110361"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119749882.ch3"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1TB02241E"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00568"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b01302"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.6b00484"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtadv.2023.100398"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm200464x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c00006"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmats.2021.671451"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201801063"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1181044"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC04166D"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/catal12121642"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic00027a012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7BM00884H"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym14061209"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/macp.202500010"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166490"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201065171\u20101"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u2010153X\u20105\u201012"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5bm01338k"}],"container-title":["Macromolecular Rapid Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.70391","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/marc.70391","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/marc.70391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:18:35Z","timestamp":1789996715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/marc.70391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":24,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/marc.70391"],"URL":"https:\/\/doi.org\/10.1002\/marc.70391","archive":["Portico"],"relation":{},"ISSN":["1022-1336","1521-3927"],"issn-type":[{"value":"1022-1336","type":"print"},{"value":"1521-3927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"2026-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70391"}}