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We discuss these systems within a structure\u2010assembly\u2010biointerface framework, emphasizing how polymer architecture, charge distribution, degradability, topology, and polymer\u2010lipid interfacial organization govern RNA packaging, nanoparticle formation, intracellular release, tissue\u2010selective interactions, and biological identity.<\/jats:p>","DOI":"10.1002\/marc.70402","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:59:44Z","timestamp":1786186784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Macromolecular Design Principles for Polymer\u2010Lipid Hybrid Nanoparticles in RNA Delivery"],"prefix":"10.1002","volume":"47","author":[{"given":"Bing","family":"Shao","sequence":"first","affiliation":[{"name":"Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of China  Hefei China"},{"name":"Department of 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