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Rapid Commun."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Triple\u2010negative breast cancer (TNBC) is a highly aggressive and lethal malignancy with poor response to conventional therapeutic regimens. Thus, there is an urgent need to develop precision theranostic nanoplatforms that integrate accurate imaging guidance with synergistic therapeutic modalities. Herein, a novel responsive multifunctional Ag\n                    <jats:sub>2<\/jats:sub>\n                    S\/MnO\n                    <jats:sub>2<\/jats:sub>\n                    @SiO\n                    <jats:sub>2<\/jats:sub>\n                    (AMS) nanofactory was constructed for NIR\u2010II fluorescence\/photoacoustic (NIR\u2010II FL\/PA) imaging\u2010guided synergistic chemodynamic\/photothermal therapy (CDT\/PTT) of TNBC. Leveraging the unique biochemical cues of the TME, AMS undergoes efficient degradation, leading to the rapid release of Ag\n                    <jats:sub>2<\/jats:sub>\n                    S and Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ions. The released Ag\n                    <jats:sub>2<\/jats:sub>\n                    S enables precise tumor localization via NIR\u2010II FL\/PA imaging, while simultaneously mediating efficient PTT upon 808\u00a0nm laser irradiation. Meanwhile, Mn\n                    <jats:sup>2+<\/jats:sup>\n                    ions exhibit Fenton\u2010like catalytic activity to convert endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    into highly toxic\n                    <jats:bold>\u2022<\/jats:bold>\n                    OH for CDT, and the hyperthermia induced by PTT further accelerates the Fenton\u2010like reaction to boost CDT efficacy, thus achieving highly efficient synergistic antitumor therapy. Collectively, the AMS nanofactory with favorable biocompatibility provides a promising strategy for precision theranostics of TNBC.\n                  <\/jats:p>","DOI":"10.1002\/marc.70434","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:04:32Z","timestamp":1789844672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TME\u2010Activated Nanofactory Orchestrate NIR\u2010II Fluorescence\/Photoacoustic Imaging\u2010Guided Synergistic Chemodynamic\/Photothermal Antitumor Therapy"],"prefix":"10.1002","author":[{"given":"Rong","family":"Dai","sequence":"first","affiliation":[{"name":"Shanxi Key Laboratory of Optical\u2010Spectral Imaging Technology and Equipment Laboratory of Molecular Imaging Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital)  Taiyuan 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