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Rapid Commun."],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Biodegradable orthopedic materials have attracted increasing attention due to their excellent biocompatibility, controllable degradation behavior, and capacity for osteointegration, enabling effective bone regeneration while eliminating the need for secondary implant\u2010removal surgery. However, bacterial colonization and subsequent dense biofilm formation on implanted scaffolds often lead to persistent infections, posing a major barrier to clinical translation. The development of antibacterial\u2010functionalized biodegradable scaffolds is therefore crucial for advancing next\u2010generation orthopedic implants. Herein, we report the fabrication of a biodegradable hybrid scaffold exhibiting synergistic chemical and second near\u2010infrared (NIR\u2010II) photothermal antibacterial activity. The scaffold was fabricated via a precisely controlled thermally induced phase separation (TIPS) technique, integrating a poly(lactic acid)\u2010poly(ethylene glycol)\u2010poly(lactic acid) (PELA) triblock copolymer, hydroxyapatite (HA), and mesoporous polydopamine microspheres modified with silver nanoparticles (Ag\u2010mPDA). The biodegradable PELA matrix establishes an optimal mechanical microenvironment for bone regeneration, while HA incorporation enhances scaffold osteoconductivity. Notably, the Ag\u2010mPDA nanoparticles exhibit a dual\u2010mode antibacterial action, combining sustained Ag\n                    <jats:sup>+<\/jats:sup>\n                    release with NIR\u2010II laser\u2010triggered photothermal effect. This synergistic chemo\u2010photothermal antibacterial strategy effectively combats implant\u2010associated bacterial infections, offering a promising and versatile platform for smart biodegradable orthopedic implants.\n                  <\/jats:p>","DOI":"10.1002\/marc.70455","type":"journal-article","created":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T04:39:57Z","timestamp":1791693597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biodegradable Hybrid Scaffolds Integrating Synergistic Chemical and NIR\u2010II Photothermal Antibacterial Activity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3395-9821","authenticated-orcid":false,"given":"Xueping","family":"Kong","sequence":"first","affiliation":[{"name":"Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials Sinopec (Beijing) Research Institute of Chemical Industry Co., Ltd.  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials Sinopec (Beijing) Research Institute of Chemical Industry Co., Ltd.  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials Sinopec (Beijing) Research Institute of Chemical Industry Co., Ltd.  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials Sinopec (Beijing) Research Institute of Chemical Industry Co., Ltd.  Beijing People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Sinopec Key Laboratory of Research and Application of Medical and Hygienic Materials Sinopec (Beijing) Research Institute of Chemical Industry Co., Ltd.  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