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Pesticides comprise a large number of substances that belong to many completely different chemical groups, the only common characteristic is that they are effective against pests. They still constitute a challenge in MS because there is no collective pathway for fragmentation. A brief introduction to the theory of tandem MS permits a discussion of which parameters influence the ionization efficiency when the ions are subjected to different actions. Emphasis is placed on the different tandem MS instruments: triple and ion\u2010trap quadrupoles, and hybrid quadrupole time\u2010of\u2010flight (Q\u2010TOF), including advantages and drawbacks, typical detection limits, and ion signals at low concentrations. The instrumental setup, as well as LC and mass spectrometric experimental conditions, must be carefully selected to increase the performance of the analytical system. The capacity of each instrument to provide useful data for the identification of pesticides, and the possibility to obtain structural information for the identification of target and non\u2010target compounds, are discussed. Finally, sample preparation techniques and examples of applications are debated to reveal the potential of the current state\u2010of\u2010the\u2010art technology, and to further promote the usefulness of tandem MS. \u00a9 2003 Wiley Periodicals, Inc., Mass Spec Rev 23:45\u201385, 2004<\/jats:p>","DOI":"10.1002\/mas.10071","type":"journal-article","created":{"date-parts":[[2003,11,14]],"date-time":"2003-11-14T17:55:42Z","timestamp":1068832542000},"page":"45-85","source":"Crossref","is-referenced-by-count":264,"title":["Environmental and food applications of LC\u2013tandem mass spectrometry in pesticide\u2010residue analysis: An overview"],"prefix":"10.1002","volume":"23","author":[{"given":"Yolanda","family":"Pic\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Blasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermina","family":"Font","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,11,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00032a020"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01296-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01392-9"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00218a019"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(99)00740-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/03067319508026244"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0231(20000315)14:5<349::AID-RCM873>3.0.CO;2-P"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00819-4"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac990130u"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1176(97)00202-4"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160101020"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0341362"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01156-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002160000579"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020600b"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(02)00312-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.315"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac000859z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac015685f"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/es990340o"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00081a009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00098a029"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/es00009a021"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.788"},{"key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/jaoac\/84.6.1903","article-title":"Determination of chlormequat in fruit samples by liquid chromatography\u2013electrospray tandem mass spectrometry","volume":"84","author":"Castro R","year":"2001","journal-title":"J AOAC Int"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)00523-4"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02490423"},{"key":"e_1_2_9_29_1","unstructured":"CEN.2002.LC\u2013MS\/MS method of analysis of chlormequat and mepiquat cation. 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