{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:20:57Z","timestamp":1785896457899,"version":"3.56.0"},"reference-count":65,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Program of Energy Research and Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mass Spectrometry Reviews"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is a growing need to develop mass spectrometric methods for the characterization of oil sands naphthenic acids (structural formulae described by C<jats:sub><jats:italic>n<\/jats:italic><\/jats:sub>H<jats:sub>2<jats:italic>n<\/jats:italic>+<jats:italic>z<\/jats:italic><\/jats:sub>O<jats:sub>2<\/jats:sub> where <jats:italic>n<\/jats:italic> is the number of carbon atoms and \u201c<jats:italic>z<\/jats:italic>\u201d is referred to as the \u201chydrogen deficiency\u201d and is equal to zero, or is a negative, even integer) present in environmental samples. This interest stems from the need to better understand their contribution to the total acid number of oil sands acids; along with assessing their toxicity in aquatic environments. Negative\u2010ion electrospray ionization has emerged as the analytical technique of choice. For infusion samples, matrix effects are particularly evident for quantification in the presence of salts and co\u2010elutants. However, such effects can be minimized for methods that employ chromatographic separation prior to mass spectrometry (MS) detection. There have been several advances for accurate identification of classes of naphthenic acid components that employ a range of MS hyphenated techniques. General trends measured for degradation of the NAs in the environment appear to be similar to those obtained with either low\u2010 or high\u2010resolution MS. Future MS research will likely focus on (i) development of more reliable quantitative methods that use chromatography and internal standards, (ii) the utility of representative model naphthenic acids as surrogates for the complex NA mixtures, and (iii) development of congener\u2010specific analysis of the principal toxic components. \u00a9 2008 Wiley Periodicals, Inc., Mass Spec Rev 28:121\u2013134, 2009<\/jats:p>","DOI":"10.1002\/mas.20185","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T15:17:16Z","timestamp":1217603836000},"page":"121-134","source":"Crossref","is-referenced-by-count":144,"title":["Mass spectrometric characterization of naphthenic acids in environmental samples: A review"],"prefix":"10.1002","volume":"28","author":[{"given":"John V.","family":"Headley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry M.","family":"Peru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark P.","family":"Barrow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9888(199612)31:12<1325::AID-JMS453>3.0.CO;2-W"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/b403880k"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(04)01439-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020388b"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac061562p"},{"key":"e_1_2_7_7_1","first-page":"1017","volume-title":"Kirk\u2010othmer encyclopaedia of chemical technology","author":"Brient JA","year":"1995"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2005.02.065"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(02)00763-4"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0146-6380(84)90126-8"},{"key":"e_1_2_7_11_1","volume-title":"Petroleum microbiology","author":"Davis JB","year":"1967"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.07.040"},{"key":"e_1_2_7_13_1","first-page":"125","article-title":"Effects of sodium naphthenate on survival and some physiological\u2010biochemical parameters of some fishes","volume":"23","author":"Dokholyan VK","year":"1983","journal-title":"J Ichthyol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1670391"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0009797"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00164a015"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef00027a003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2675315"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00289a008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.01.041"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1081\/ESE-120039370"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac070905w"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jaoac\/85.1.182"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4296\/cwrj2701025"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef0504321"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1139\/m94-076"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0043-1354(01)00492-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef9901746"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef00027a007"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2670(92)85299-L"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac010560w"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10934520600620105"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac60206a048"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac034415p"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orggeochem.2005.03.010"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.5620150909"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ef034004b"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac030093d"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2005.12.008"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.2166\/wqrj.1986.043"},{"key":"e_1_2_7_41_1","volume-title":"Electrospray mass spectrometry. 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