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Therefore, following the recent review on the class\u2010specific fragmentation of toxicologically relevant compounds in positive\u2010ion MS\u2013MS, it was decided to perform a similar study in negative\u2010ion MS\u2013MS. To this end, a set of over 500 negative\u2010ion MS\u2013MS spectra was collected from three libraries applied in toxicological general unknown screening and systematic toxicological analysis. The compounds involved were classified by chemical and therapeutic class. The MS\u2013MS spectra were manually interpreted and relevant interpretation data were searched for in the scientific literature. The emphasis in the discussion is on class\u2010specific fragmentation, because discussing fragmentation of all individual compounds would take far too much space. 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