{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T13:31:59Z","timestamp":1792762319315,"version":"4.5.0"},"reference-count":160,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T00:00:00Z","timestamp":1429142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mass Spectrometry Reviews"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Urine metabolomics has recently emerged as a prominent field for the discovery of non\u2010invasive biomarkers that can detect subtle metabolic discrepancies in response to a specific disease or therapeutic intervention. Urine, compared to other biofluids, is characterized by its ease of collection, richness in metabolites and its ability to reflect imbalances of all biochemical pathways within the body. Following urine collection for metabolomic analysis, samples must be immediately frozen to quench any biogenic and\/or non\u2010biogenic chemical reactions. According to the aim of the experiment; sample preparation can vary from simple procedures such as filtration to more specific extraction protocols such as liquid\u2010liquid extraction. Due to the lack of comprehensive studies on urine metabolome stability, higher storage temperatures (i.e. 4\u00b0C) and repetitive freeze\u2010thaw cycles should be avoided. To date, among all analytical techniques, mass spectrometry (MS) provides the best sensitivity, selectivity and identification capabilities to analyze the majority of the metabolite composition in the urine. Combined with the qualitative and quantitative capabilities of MS, and due to the continuous improvements in its related technologies (i.e. ultra high\u2010performance liquid chromatography [UPLC] and hydrophilic interaction liquid chromatography [HILIC]), liquid chromatography (LC)\u2010MS is unequivocally the most utilized and the most informative analytical tool employed in urine metabolomics. Furthermore, differential isotope tagging techniques has provided a solution to ion suppression from urine matrix thus allowing for quantitative analysis. In addition to LC\u2010MS, other MS\u2010based technologies have been utilized in urine metabolomics. These include direct injection (infusion)\u2010MS, capillary electrophoresis\u2010MS and gas chromatography\u2010MS. In this article, the current progresses of different MS\u2010based techniques in exploring the urine metabolome as well as the recent findings in providing potentially diagnostic urinary biomarkers are discussed. \u00a9 2015 Wiley Periodicals, Inc. Mass Spec Rev 36:115\u2013134, 2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mas.21455","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T10:21:29Z","timestamp":1429179689000},"page":"115-134","source":"Crossref","is-referenced-by-count":327,"title":["Mass spectrometric based approaches in urine metabolomics and biomarker discovery"],"prefix":"10.1002","volume":"36","author":[{"given":"Mona M.","family":"Khamis","sequence":"first","affiliation":[{"name":"College of Pharmacy and Nutrition University of Saskatchewan 107 Wiggins Rd Saskatoon SK S7N 5E5 Canada"},{"name":"Faculty of Pharmacy Alexandria University Alexandria 21521 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl J.","family":"Adamko","sequence":"additional","affiliation":[{"name":"Department of Pediatrics College of Medicine University of Saskatchewan 103 Hospital Drive Saskatoon SK Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"El\u2010Aneed","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Nutrition University of Saskatchewan 107 Wiggins Rd Saskatoon SK S7N 5E5 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-007-0091-1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5630-y"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.08.041"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/1522-2683(200105)22:7<1251::AID-ELPS1251>3.0.CO;2-9","article-title":"Recent advances in capillary electrophoresis\/electrospray\u2010mass spectrometry","volume":"22","author":"Bayer E","year":"2001","journal-title":"Electrophoresis"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.01.024"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-008-0756-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac9011599"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10858-011-9489-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2005.05.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298669391355134"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201200571"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/39.12.2503"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504921102"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073076"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1955.6"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-5308-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004670000551"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.03.039"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.08.012"},{"key":"e_1_2_9_21_1","article-title":"Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma","volume":"10","author":"Chen T","year":"2011","journal-title":"Mol Cell Proteomics"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2008.12.026"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-2697(02)00275-0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/33.1.1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac301984t"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20108"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1478-3975\/5\/1\/011001"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym281"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1039\/B906712B"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2004.11.021"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-012-0434-4"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac801429w"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-010-3575-1"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2012.08.011"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/81137"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-007-0070-6"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac010501i"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200700644"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.10.066"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737159.8.5.617"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200905579"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920012803341401"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0704356"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac900166a"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac102146g"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/eri069"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-008-0104-8"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2007.04.001"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4710"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.08.008"},{"key":"e_1_2_9_51_1","first-page":"141","volume-title":"Biological monitoring: an introduction","author":"Hee SQ","year":"1993"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-008-0135-1"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06882"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2011.06.027"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22954"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902017067"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac020101a"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-685-6"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4034"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24002"},{"key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/clinchem\/29.2.392","article-title":"Particulate and free enzyme activity in urine as a result of the shedding of brush\u2010border membranes from kidney","volume":"29","author":"Jung K","year":"1983","journal-title":"Clin Chim"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2007.04.021"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2010.0094"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-013-6856-7"},{"key":"e_1_2_9_65_1","first-page":"1","article-title":"Direct infusion mass spectrometry metabolomics dataset: a benchmark for data processing and quality control","author":"Kirwan JA","year":"2014","journal-title":"Scientific Data"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.11.028"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac201980w"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac011250g"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1746"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2010.09.031"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.11.063"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.635"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac061354x"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R111.238691"},{"key":"e_1_2_9_75_1","first-page":"217","article-title":"Evaluation of urinary lead concentrations. I. The significance of the specific gravity","volume":"27","author":"Levine L","year":"1945","journal-title":"J Ind Hyg Toxicol"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.04.031"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2010.02.021"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467211205020301"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032292"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986713804806621"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasms.2009.04.020"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70038-X"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp558"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr901173v"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3314"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.07.045"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2008.07.077"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900270"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2407"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V11101882"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1039\/b501767j"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1250"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1154"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201000378"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800512"},{"key":"e_1_2_9_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.201200390"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1571"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac900874m"},{"key":"e_1_2_9_99_1","volume-title":"Targeted metabolomics. Current Protocols in Molecular Biology","author":"Roberts LD","year":"2012"},{"key":"e_1_2_9_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.06.067"},{"key":"e_1_2_9_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.08.016"},{"key":"e_1_2_9_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2010.10.035"},{"key":"e_1_2_9_103_1","first-page":"(1)","article-title":"Derivatization in liquid chromatography for mass spectrometric detection","volume":"7","author":"Santa T","year":"2013","journal-title":"Drug Discoveries Ther"},{"key":"e_1_2_9_104_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200711-1716OC"},{"key":"e_1_2_9_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1077"},{"key":"e_1_2_9_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-009-0168-0"},{"key":"e_1_2_9_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2787(1998)17:3<131::AID-MAS1>3.0.CO;2-O"},{"key":"e_1_2_9_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac071016b"},{"key":"e_1_2_9_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.01.027"},{"key":"e_1_2_9_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0708588"},{"key":"e_1_2_9_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr034020m"},{"key":"e_1_2_9_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07762"},{"key":"e_1_2_9_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.392"},{"key":"e_1_2_9_114_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.147751"},{"key":"e_1_2_9_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2013.01.111"},{"key":"e_1_2_9_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10545-005-0111-0"},{"key":"e_1_2_9_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-006-0042-2"},{"key":"e_1_2_9_118_1","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20306"},{"key":"e_1_2_9_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2011.09.042"},{"key":"e_1_2_9_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.04.018"},{"key":"e_1_2_9_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3219"},{"key":"e_1_2_9_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3266"},{"key":"e_1_2_9_123_1","doi-asserted-by":"publisher","DOI":"10.4172\/2157-7064.1000144"},{"key":"e_1_2_9_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja036006g"},{"key":"e_1_2_9_125_1","doi-asserted-by":"publisher","DOI":"10.1667\/RR1703.1"},{"key":"e_1_2_9_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0043-1354(03)00065-4"},{"key":"e_1_2_9_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.07.058"},{"key":"e_1_2_9_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2008.09.002"},{"key":"e_1_2_9_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2006.02816.x"},{"key":"e_1_2_9_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-010-0151-3"},{"key":"e_1_2_9_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-003-0495-9"},{"key":"e_1_2_9_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo1010003"},{"key":"e_1_2_9_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-6039-y"},{"key":"e_1_2_9_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2797(98)00097-0"},{"key":"e_1_2_9_135_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac051705s"},{"key":"e_1_2_9_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100333"},{"key":"e_1_2_9_137_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M111.016006"},{"key":"e_1_2_9_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.50"},{"key":"e_1_2_9_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.01.007"},{"key":"e_1_2_9_140_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.2.e7"},{"key":"e_1_2_9_141_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.156.9.893"},{"key":"e_1_2_9_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr049769r"},{"key":"e_1_2_9_143_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1065"},{"key":"e_1_2_9_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(03)00713-1"},{"key":"e_1_2_9_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.09.067"},{"key":"e_1_2_9_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.10.014"},{"key":"e_1_2_9_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2009.06.033"},{"key":"e_1_2_9_148_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac3025625"},{"key":"e_1_2_9_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac050697c"},{"key":"e_1_2_9_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00539-1"},{"key":"e_1_2_9_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2008.02.009"},{"key":"e_1_2_9_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200800156"},{"key":"e_1_2_9_153_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2320403"},{"key":"e_1_2_9_154_1","doi-asserted-by":"publisher","DOI":"10.1039\/C1AN15605E"},{"key":"e_1_2_9_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.08.016"},{"key":"e_1_2_9_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac2030738"},{"key":"e_1_2_9_157_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0746"},{"key":"e_1_2_9_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijms.2012.02.019"},{"key":"e_1_2_9_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2009.11.003"},{"key":"e_1_2_9_160_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac403000n"},{"key":"e_1_2_9_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac5009089"}],"container-title":["Mass Spectrometry Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmas.21455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmas.21455","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mas.21455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T12:10:57Z","timestamp":1760962257000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/mas.21455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,16]]},"references-count":160,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/mas.21455"],"URL":"https:\/\/doi.org\/10.1002\/mas.21455","archive":["Portico"],"relation":{},"ISSN":["0277-7037","1098-2787"],"issn-type":[{"value":"0277-7037","type":"print"},{"value":"1098-2787","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,16]]}}}