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It is very difficult to clarify molecular mechanism and treat PAs from the single\u2010factor strategy model. The rapid development of multiomics and systems biology changed the paradigms from a traditional single\u2010factor strategy to a multiparameter systematic strategy for effective management of PAs. A series of molecular alterations at the genome, transcriptome, proteome, peptidome, metabolome, and radiome levels are involved in pituitary tumorigenesis, and mutually associate into a complex molecular network system. Also, the center of multiomics is moving from structural genomics to phenomics, including proteomics and metabolomics in the medical sciences. Mass spectrometry (MS) has been extensively used in phenomics studies of human PAs to clarify molecular mechanisms, and to discover biomarkers and therapeutic targets\/drugs. MS\u2010based proteomics and proteoform studies play central roles in the multiomics strategy of PAs. This article reviews the status of multiomics, multiomics\u2010based molecular pathway networks, molecular pathway network\u2010based pattern biomarkers and therapeutic targets\/drugs, and future perspectives for personalized, predeictive, and preventive (3P) medicine in PAs.<\/jats:p>","DOI":"10.1002\/mas.21710","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T16:51:08Z","timestamp":1623343868000},"page":"964-1013","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The use of mass spectrometry in a proteome\u2010centered multiomics study of human pituitary adenomas"],"prefix":"10.1002","volume":"41","author":[{"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"Shandong Key Laboratory of Radiation Oncology, Cancer Hospital of Shandong First Medical University Jinan Shandong China"},{"name":"Medical Science and Technology Innovation Center Shandong First Medical University Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic M.","family":"Desiderio","sequence":"additional","affiliation":[{"name":"The Charles B. 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