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SARS\u2010CoV\u20102 encodes four structural proteins namely membrane, nucleocapsid, spike, and envelope proteins that play essential roles in viral entry, fusion, and attachment to the host cell. Extensively glycosylated spike protein efficiently binds to the host angiotensin\u2010converting enzyme 2 initiating viral entry and pathogenesis. Reverse transcriptase polymerase chain reaction on nasopharyngeal swab is the preferred method of sample collection and viral detection because it is a rapid, specific, and high\u2010throughput technique. Alternate strategies such as proteomics and glycoproteomics\u2010based mass spectrometry enable a more detailed and holistic view of the viral proteins and host\u2013pathogen interactions and help in detection of potential disease markers. In this review, we highlight the use of mass spectrometry methods to profile the SARS\u2010CoV\u20102 proteome from clinical nasopharyngeal swab samples. 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