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This transition from a reductionist to a global\u2010integrative approach is conditioned to the capability of proteomic platforms to generate and analyze complete qualitative and quantitative proteomics data. Paradoxically, the underlying analytical technique, molecular mass spectrometry, is inherently nonquantitative. The turn of the century witnessed the development of analytical strategies to endow proteomics with the ability to quantify proteomes of model organisms in the sense of \u201can organism for which comprehensive molecular (genomic and\/or transcriptomic) resources are available.\u201d This essay presents an overview of the strategies and the lights and shadows of the most popular quantification methods highlighting the common misuse of label\u2010free approaches developed for model species' when applied to quantify the individual components of proteomes of nonmodel species (In this essay we use the term \u201cnon\u2010model\u201d organisms for species lacking comprehensive molecular (genomic and\/or transcriptomic) resources, a circumstance that, as we detail in this review\u2010essay, conditions the quantification of their proteomes.). We also point out the opportunity of combining elemental and molecular mass spectrometry systems into a hybrid instrumental configuration for the parallel identification and absolute quantification of venom proteomes. The successful application of this novel mass spectrometry configuration in snake venomics represents a proof\u2010of\u2010concept for a broader and more routine application of hybrid elemental\/molecular mass spectrometry setups in other areas of the proteomics field, such as phosphoproteomics, metallomics, and in general in any biological process where a heteroatom (i.e., any atom other than C, H, O, N) forms integral part of its mechanism.<\/jats:p>","DOI":"10.1002\/mas.21850","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T13:47:22Z","timestamp":1683553642000},"page":"977-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Quantification of snake venom proteomes by mass spectrometry\u2010considerations and perspectives"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5026-3122","authenticated-orcid":false,"given":"Juan 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