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Among the diseases that affect citriculture, Asiatic citrus canker, caused by the bacterial pathogen Xanthomonas citri, represents one of the most significant threats. The current Brazilian legislation regulating the control of citrus canker no longer requires the eradication of affected trees in states where the incidence of the disease is high. Instead, control involves disease control measures, including periodic preventative spraying of copper compounds. The long\u2010term use of copper for plant disease control has raised concerns about environmental accumulation and toxicity, as well as the selective pressure it exerts leading to the emergence of copper\u2010resistant X.\u00a0citri strains. Here, we evaluated hexyl gallate (G6) as an alternative to copper compounds for citrus plant protection. G6 was able to protect citrus nursery trees against X.\u00a0citri infection. Thirty days after inoculation, the trees treated with G6 developed 0.5\u00a0lesions\/cm<jats:sup>2<\/jats:sup> leaf area compared with the 2.84\u00a0lesions\/cm<jats:sup>2<\/jats:sup> observed in the untreated control trees. Also, G6 did not interfere with germination and root development of tomato, lettuce, and arugula, which is consistent with our previous data showing that G6 is safe for tissue culture cell lines. Membrane permeability tests showed that the primary target of G6 is the bacterial outer membrane. Finally, we could not isolate spontaneous X.\u00a0citri mutants resistant to G6 nor induce resistance to G6 after long\u2010term exposures to increasing concentrations of the compound, which suggests that G6 may have multiple cellular targets. This study demonstrated that G6 is a promising candidate for the development and use in citrus canker management.<\/jats:p>","DOI":"10.1002\/mbo3.1104","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T07:21:09Z","timestamp":1596698469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hexyl gallate for the control of citrus canker caused by <i>Xanthomonas citri<\/i> subsp <i>citri<\/i>"],"prefix":"10.1002","volume":"9","author":[{"given":"L\u00facia B.","family":"Cavalca","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Microbiologia Instituto de Bioci\u00eancias Universidade Estadual Paulista Rio Claro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio F. C.","family":"Zamuner","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Microbiologia Instituto de Bioci\u00eancias Universidade Estadual Paulista Rio Claro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz L.","family":"Saldanha","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Microbiologia Instituto de Bioci\u00eancias Universidade Estadual Paulista Rio Claro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos R.","family":"Polaquini","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica e Ci\u00eancias Ambientais Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas Universidade Estadual Paulista S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis O.","family":"Regasini","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica e Ci\u00eancias Ambientais Instituto de Bioci\u00eancias, Letras e Ci\u00eancias Exatas Universidade Estadual Paulista S\u00e3o Jos\u00e9 do Rio Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Behlau","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Development Fundo de Defesa da Citricultura (Fundecitrus) Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-9420","authenticated-orcid":false,"given":"Henrique","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Microbiologia Instituto de Bioci\u00eancias Universidade Estadual Paulista Rio Claro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.01.014"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00198282"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3059.2010.02344.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2009.12.010"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-012-9966-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.03043-10"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO-06-12-0134-R"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10658-011-9870-7"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2017.01.003"},{"key":"e_1_2_10_11_1","volume-title":"Proceedings of the international workshop on Xanthomonas citri\/citrus canker. 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