{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:31:06Z","timestamp":1777505466243,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008900","name":"University of South Florida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008900","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital Zika syndrome is caused by mother\u2010to\u2010fetus transmission of the Zika virus (ZIKV). Peripheral blood mononuclear cells (PBMCs) are permissive to ZIKV infection and may carry ZIKV to the placenta. To identify pregnancy\u2010related differences in PBMC responses against ZIKV infection, we compared gene expression profiles of ZIKV\u2010infected and non\u2010infected PBMCs cultured from pregnant and non\u2010pregnant women. ZIKV\u2010infected pregnant conditions generally overexpressed M1\u2010shifted pro\u2010inflammatory responses and underexpressed M2\u2010shifted anti\u2010inflammatory responses. Additionally, transcripts involved in osteoclast differentiation and cardiac myopathies were upregulated following ZIKV infection. Our results suggest potential roles of pregnancy\u2010induced immune dysregulation in shaping neonatal pathology associated with ZIKV infection.<\/jats:p>","DOI":"10.1002\/mbo3.1134","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T04:49:03Z","timestamp":1605847743000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gene expression responses to Zika virus infection in peripheral blood mononuclear cells from pregnant and non\u2010pregnant women"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4578-5318","authenticated-orcid":false,"given":"Shen Jean","family":"Lim","sequence":"first","affiliation":[{"name":"College of Nursing University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6231-9955","authenticated-orcid":false,"given":"Andreas","family":"Seyfang","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine Morsani College of Medicine University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4987-4169","authenticated-orcid":false,"given":"Samia","family":"Dutra","sequence":"additional","affiliation":[{"name":"College of Nursing University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Kane","sequence":"additional","affiliation":[{"name":"College of Nursing University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-2927","authenticated-orcid":false,"given":"Maureen","family":"Groer","sequence":"additional","affiliation":[{"name":"College of Nursing University of South Florida Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180722"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw7733"},{"key":"e_1_2_10_6_1","first-page":"263","article-title":"Much more than M1 and M2 macrophages, there are also CD169(+) and TCR(+) macrophages","volume":"6","author":"Chavez\u2010Galan L.","year":"2015","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.4.621"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1113"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0016-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-012465330-6\/50003-8"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.09.098"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242676"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00514"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00500"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3711"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.1.142"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2016.11.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1213566"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2205.160065"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw448"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp352"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.470"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2016.0004"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-019-4622-y"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0035-0"},{"issue":"6","key":"e_1_2_10_27_1","first-page":"e1399","article-title":"Association of Zika virus with myocarditis, heart failure, and arrhythmias: A literature review","volume":"9","author":"Minhas A. M.","year":"2017","journal-title":"Cureus"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.041"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1814416"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12570"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01621"},{"key":"e_1_2_10_32_1","article-title":"Dysregulation of long non\u2010coding RNA (lncRNA) genes and predicted lncRNA\u2010protein interactions during Zika virus infection","volume":"061788","author":"Ramaiah A.","year":"2016","journal-title":"bioRxiv"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2010-11-3-r25"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/816460"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00997.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59643"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12355"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.5"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74856-1_9"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903597"},{"issue":"12","key":"e_1_2_10_42_1","first-page":"1890","article-title":"Persistent Plasmodium falciparum infection in women with an intent to become pregnant as a risk factor for pregnancy\u2010associated malaria","volume":"67","author":"Tuikue Ndam N.","year":"2018","journal-title":"Clinical Infectious Diseases"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1049"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252784499"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/v9110338"}],"container-title":["MicrobiologyOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.1134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mbo3.1134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.1134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T12:58:16Z","timestamp":1693745896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.1134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,19]]},"references-count":44,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1002\/mbo3.1134"],"URL":"https:\/\/doi.org\/10.1002\/mbo3.1134","archive":["Portico"],"relation":{},"ISSN":["2045-8827","2045-8827"],"issn-type":[{"value":"2045-8827","type":"print"},{"value":"2045-8827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,19]]},"assertion":[{"value":"2020-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1134"}}