{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:59:08Z","timestamp":1768823948322,"version":"3.49.0"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The enormous complexity of the eukaryotic ribosome has been a real challenge in unlocking the mechanistic aspects of its amazing molecular function during mRNA translation and many non\u2010canonical activities of ribosomal proteins in eukaryotic cells. While exploring the uncanny nature of ribosomal P proteins in malaria parasites <jats:italic>Plasmodium falciparum<\/jats:italic>, the 60S stalk ribosomal P2 protein has been shown to get exported to the infected erythrocyte (IE) surface as an SDS\u2010resistant oligomer during the early to the mid\u2010trophozoite stage. Inhibiting IE surface P2 either by monoclonal antibody or through genetic knockdown resulted in nuclear division arrest of the parasite. This strange and serendipitous finding has led us to explore more about un\u2010canonical cell biology and the structural involvement of P2 protein in <jats:italic>Plasmodium<\/jats:italic> in the search for a novel biochemical role during parasite propagation in the human host.<\/jats:p>","DOI":"10.1002\/mbo3.1188","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T02:32:32Z","timestamp":1629685952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010ribosomal insights into ribosomal P2 protein in <i>Plasmodium falciparum<\/i>\u2010infected erythrocytes"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-7342","authenticated-orcid":false,"given":"Sudipta","family":"Das","sequence":"first","affiliation":[{"name":"Asymmetric Cell Division Laboratory Division of Infectious Disease and Immunology CSIR\u2010Indian Institute of Chemical Biology Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhaskar","family":"Roy","sequence":"additional","affiliation":[{"name":"Asymmetric Cell Division Laboratory Division of Infectious Disease and Immunology CSIR\u2010Indian Institute of Chemical Biology Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saswata","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Asymmetric Cell Division Laboratory Division of Infectious Disease and Immunology CSIR\u2010Indian Institute of Chemical Biology Kolkata India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06661.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13574"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2012.07.004"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.09.004"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.051"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08728"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.06.030"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4312-4318.2000"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07572.x"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23217"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002858"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.384388"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2012.01790.x"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2014.01.003"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13646"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.015"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/yea.1765"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0222-7"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2420"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0248-4900(03)00034-0"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.12138"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05675-5"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.09.010"},{"issue":"3","key":"e_1_2_12_25_1","article-title":"CLAG3 self\u2010associates in malaria parasites and quantitatively determines nutrient uptake channels at the host membrane","volume":"9","author":"Gupta A.","year":"2018","journal-title":"Mbio"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06582.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2016.04.013"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(01)00251-X"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405718200"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003546"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102737"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0469-4"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12049"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23485"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000053"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084219"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2005.05.003"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/pce.12742"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-091014-104506"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.276.5315.1122"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.62.2.651-656.1994"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1102452"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20080049"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2015.03.010"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036279"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2020.07.007"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866521666141121160523"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2013.782827"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5769(00)00048-9"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.22.6075"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2010.01.003"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07278.x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1139\/o95-103"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)49806-2"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp806"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08726"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)40736-8"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.35.20608"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00860.x"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23239"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(01)00394-2"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034157"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00095-06"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2003.10.009"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2014.08.006"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9264217"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65282"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000118"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12133"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(02)00133-4"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)41758-9"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5473.2045"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.009"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)20011-8"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7847"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33720-1"}],"container-title":["MicrobiologyOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.1188","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mbo3.1188","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.1188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:32:57Z","timestamp":1693290777000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.1188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/mbo3.1188"],"URL":"https:\/\/doi.org\/10.1002\/mbo3.1188","archive":["Portico"],"relation":{},"ISSN":["2045-8827","2045-8827"],"issn-type":[{"value":"2045-8827","type":"print"},{"value":"2045-8827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"2021-04-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1188"}}