{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:46:12Z","timestamp":1790444772128,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009360","name":"King\u2019s College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009360","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Invasive <jats:italic>Candida<\/jats:italic> infections in hospitalized and immunocompromised or critically ill patients have become an important cause of morbidity and mortality. There are increasing reports of multidrug resistance in several <jats:italic>Candida<\/jats:italic> species that cause Candidemia, including <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>glabrata<\/jats:italic> and <jats:italic>C.\u00a0auris<\/jats:italic>, with limited numbers of antifungal agents available to treat patients with invasive Candida infections. Therefore, there is an urgent need to discover new antifungal agents that work against multidrug\u2010resistant <jats:italic>Candida<\/jats:italic> species, particularly <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>auris<\/jats:italic>, which has been identified as an emerging global pathogen. In this article, we report a new class of antifungal agents, the Schiff bases of sulphonamides, that show activity against all <jats:italic>Candida<\/jats:italic> species tested, with an MIC range of 4\u201332\u00a0\u00b5g\/ml. Compound <jats:bold>2b<\/jats:bold> showed activity against <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>glabrata<\/jats:italic> and a panel of fluconazole\u2010resistant <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>auris<\/jats:italic> strains, with MICs of 4\u201316\u00a0\u00b5g\/ml. The drug\u2010like nature of these Schiff bases offers opportunities to optimize these compounds with medicinal chemistry techniques to obtain more potent analogs that can be progressed toward pre\u2010clinical evaluation.<\/jats:p>","DOI":"10.1002\/mbo3.1218","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T17:35:34Z","timestamp":1627061734000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Schiff bases of sulphonamides as a new class of antifungal agent against multidrug\u2010resistant <i>Candida auris<\/i>"],"prefix":"10.1002","volume":"10","author":[{"given":"Asad","family":"Hamad","sequence":"first","affiliation":[{"name":"Department of Pharmacy The Islamia University of Bahawalpur  Bahawalpur Pakistan"},{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy The Islamia University of Bahawalpur  Bahawalpur Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Saeed","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Science King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Clifford","sequence":"additional","affiliation":[{"name":"Public Health England National Infections Service  Salisbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Hind","sequence":"additional","affiliation":[{"name":"Public Health England National Infections Service  Salisbury UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2288-0446","authenticated-orcid":false,"given":"J. 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