{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:52:11Z","timestamp":1772995931185,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T00:00:00Z","timestamp":1495152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Next-Generation BioGreen 21 Progra","award":["PJ011800"],"award-info":[{"award-number":["PJ011800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Streptomyces griseus<\/jats:italic>S4\u20107 was originally isolated from the strawberry rhizosphere as a microbial agent responsible for Fusarium wilt suppressive soils.<jats:italic>S.\u00a0griseus<\/jats:italic>S4\u20107 shows specific and pronounced antifungal activity against<jats:italic>Fusarium oxysporum<\/jats:italic>f. sp.<jats:italic>fragariae<\/jats:italic>. In the<jats:italic>Streptomyces<\/jats:italic>genus, the<jats:italic>whi<\/jats:italic>transcription factors are regulators of sporulation, cell differentiation, septation, and secondary metabolites production.<jats:italic>wblE2<\/jats:italic>function as a regulator has emerged as a new group in<jats:italic>whi<\/jats:italic>transcription factors. In this study, we reveal the involvement of the<jats:italic>wblE2<\/jats:italic>transcription factor in the plant\u2010protection by<jats:italic>S.\u00a0griseus<\/jats:italic>S4\u20107. We generated \u0394<jats:italic>wblE<\/jats:italic>, \u0394<jats:italic>wblE2<\/jats:italic>, \u0394<jats:italic>whiH<\/jats:italic>, and \u0394<jats:italic>whmD<\/jats:italic>gene knock\u2010out mutants, which showed less antifungal activity both in vitro and<jats:italic>in planta<\/jats:italic>. Among the mutants,<jats:italic>wblE<\/jats:italic>2 mutant failed to protect the strawberry against the Fusarium wilt pathogen. Transcriptome analyses revealed major differences in the regulation of phenylalanine metabolism, polyketide and siderophore biosynthesis between the S4\u20107 and the<jats:italic>wblE<\/jats:italic>2 mutant. The results contribute to our understanding of the role of streptomycetes<jats:italic>wblE2<\/jats:italic>genes in a natural disease suppressing system.<\/jats:p>","DOI":"10.1002\/mbo3.494","type":"journal-article","created":{"date-parts":[[2017,5,19]],"date-time":"2017-05-19T06:39:47Z","timestamp":1495175987000},"source":"Crossref","is-referenced-by-count":10,"title":["<i>wblE2<\/i>transcription factor in<i>Streptomyces griseus<\/i>S4\u20107 plays an important role in plant protection"],"prefix":"10.1002","volume":"6","author":[{"given":"Hyun Ji","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Applied Life Science (BK21 Plue) and IALS Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Sang","family":"Kwon","sequence":"additional","affiliation":[{"name":"Environmental Chemistry Research Center Korea Institute of Toxicology Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da\u2010Ran","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plant Medicine Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeongjun","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Applied Life Science (BK21 Plue) and IALS Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Won","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Applied Life Science (BK21 Plue) and IALS Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Won","family":"Bae","sequence":"additional","affiliation":[{"name":"Center for Research Facilities Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-1808","authenticated-orcid":false,"given":"Youn\u2010Sig","family":"Kwak","sequence":"additional","affiliation":[{"name":"Division of Applied Life Science (BK21 Plue) and IALS Gyeongsang National University Jinju Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2007.05589.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5326.653"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2005.02.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20130214"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(92)90627-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.302588"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2015.95"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03476.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi901498v"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4511"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2004.10.013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1968"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1139\/m83-103"},{"key":"e_1_2_7_16_1","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195150667.001.0001","volume-title":"Streptomyces in Nature and Medicine: The Antibiotic Makers","author":"Hopwood D. 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