{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:21:57Z","timestamp":1780734117105,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,30]],"date-time":"2017-08-30T00:00:00Z","timestamp":1504051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM104834\u201001"],"award-info":[{"award-number":["GM104834\u201001"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>With the overuse of antibiotics, many pathogens including <jats:italic>Vibrio cholerae<\/jats:italic> and <jats:italic>Vibrio parahaemolyticus<\/jats:italic> have evolved multidrug resistance making treatment more difficult. While understanding the mechanisms that underlie pathogenesis is crucial, knowledge of bacterial interactions of <jats:italic>V.\u00a0cholerae<\/jats:italic> and <jats:italic>V.\u00a0parahaemolyticus<\/jats:italic> could provide insight to their susceptibility outside of the human host. Based on previous work showing competition among environmental strains, we predict that marine\u2010derived bacteria should inhibit <jats:italic>Vibrio<\/jats:italic> pathogens and may be a source of unique antibiotic compounds. We tested a collection of 3,456 environmental <jats:italic>Vibrio<\/jats:italic> isolates from diverse habitats against a panel of <jats:italic>V.\u00a0cholerae<\/jats:italic> and <jats:italic>V.\u00a0parahaemolyticus<\/jats:italic>, and identified 102 strains that inhibited the growth of these pathogens. Phylogenetic analysis revealed that 40 pathogen\u2010inhibiting strains were unique at the <jats:italic>hsp60<\/jats:italic> gene sequence while 62 of the isolates were identical suggesting clonal groups. Genomic comparisons of ten strains revealed diversity even between clonal isolates and were identified as being closely related to known <jats:italic>Vibrio crassostreae<\/jats:italic>,<jats:italic> Vibrio splendidus<\/jats:italic>, and <jats:italic>Vibrio tasmaniensis<\/jats:italic> strains. Further analysis revealed multiple biosynthetic gene clusters within all sequenced genomes that encoded secondary metabolites with potential antagonistic activity. Thus, environmental vibrios represent a source of compounds that inhibit <jats:italic>Vibrio<\/jats:italic> pathogens.<\/jats:p>","DOI":"10.1002\/mbo3.504","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T11:55:03Z","timestamp":1504180503000},"source":"Crossref","is-referenced-by-count":13,"title":["Environmental vibrios represent a source of antagonistic compounds that inhibit pathogenic <i>Vibrio cholerae<\/i> and <i>Vibrio parahaemolyticus<\/i> strains"],"prefix":"10.1002","volume":"6","author":[{"given":"David J.","family":"Burks","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of North Texas  Denton Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bowling Green State University  Bowling Green Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Kauffman","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Massachusetts Institute of Technology  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Joy","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bowling Green State University  Bowling Green Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Arevalo","sequence":"additional","affiliation":[{"name":"Department of Civil and Environmental Engineering Massachusetts Institute of Technology  Cambridge Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K.","family":"Azad","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of North Texas  Denton Texas"},{"name":"Department of Mathematics University of North Texas  Denton Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-3820","authenticated-orcid":false,"given":"Hans","family":"Wildschutte","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Bowling Green State University  Bowling Green Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00066-06"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.6.2209-2214.2005"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004787"},{"key":"e_1_2_5_5_1","first-page":"774","article-title":"Multidrug resistance in Vibrio cholerae","volume":"33","author":"Anand V. 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