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Our previous studies show that extracellular\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">eDNA<\/jats:styled-content>\n                    ) and\n                    <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content>\n                    proteins are essential components of biofilms formed by\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    . The\n                    <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content>\n                    protein family includes integration host factor (\n                    <jats:styled-content style=\"fixed-case\">IHF<\/jats:styled-content>\n                    ) and the histone\u2010like protein\n                    <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>\n                    and plays a central role in\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    biofilm structural integrity. We demonstrated that immunological targeting of these proteins during\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    \u2010induced experimental\n                    <jats:styled-content style=\"fixed-case\">OM<\/jats:styled-content>\n                    in a chinchilla model caused rapid clearance of biofilms from the middle ear. Given the essential role of\n                    <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content>\n                    proteins in maintaining the structure of an\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    biofilm, we investigated whether any of the other nucleoid associated proteins (\n                    <jats:styled-content style=\"fixed-case\">NAP<\/jats:styled-content>\n                    s) expressed by\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    might play a similar role, thereby serving as additional target(s) for intervention. We demonstrated that although several\n                    <jats:styled-content style=\"fixed-case\">NAP<\/jats:styled-content>\n                    s including H\u2010\n                    <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n                    , CbpA, HfQ and Dps are present within the biofilm extracellular matrix, only the\n                    <jats:styled-content style=\"fixed-case\">DNABII<\/jats:styled-content>\n                    family of proteins is critical for the structural integrity of the biofilms formed by\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    . We have also demonstrated that\n                    <jats:styled-content style=\"fixed-case\">IHF<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>\n                    are located at distinct regions within the extracellular matrix of\n                    <jats:styled-content style=\"fixed-case\">NTHI<\/jats:styled-content>\n                    biofilms formed in vitro, indicative of independent functions of these two proteins.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.563","type":"journal-article","created":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T03:11:31Z","timestamp":1513048291000},"source":"Crossref","is-referenced-by-count":59,"title":["The\n                    <scp>DNABII<\/scp>\n                    family of proteins is comprised of the only nucleoid associated proteins required for nontypeable\n                    <i>Haemophilus influenzae<\/i>\n                    biofilm structure"],"prefix":"10.1002","volume":"7","author":[{"given":"Aishwarya","family":"Devaraj","sequence":"first","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Buzzo","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Rocco","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren O.","family":"Bakaletz","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3889-2369","authenticated-orcid":false,"given":"Steven D.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Center for Microbial Pathogenesis The Research Institute at Nationwide Children's Hospital and The Ohio State University College of Medicine  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.181.20.6361-6370.1999"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.46.33105"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2012.03.001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(96)00298-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1128\/iai.56.2.331-335.1988","article-title":"Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium","volume":"56","author":"Bakaletz L. 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