{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:40:18Z","timestamp":1792197618296,"version":"4.4.0"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    From 2009,\n                    <jats:italic>Candida auris<\/jats:italic>\n                    has emerged as a multidrug\u2010resistant ascomycete yeast pathogen with the capacity for easy transmission between patients and hospitals, as well as persistence on environmental surfaces. Its association with high mortalities, breakthrough and persistent candidaemia, inconsistencies in susceptibility testing results, misidentification by available commercial identification systems and treatment failure, complicates its management and detection. Within the last nine years,\n                    <jats:italic>C. auris<\/jats:italic>\n                    has been increasingly reported from far\u2010Eastern Asia, the Middle East, Africa, Europe, South and North America with substantial fatalities and misidentification. Herein, I provide a systematic and thorough review of this emerging pathogen. Meta\u2010analysis showed that at least 742\n                    <jats:italic>C. auris<\/jats:italic>\n                    isolates have been reported in 16 countries, with most of these being from India (\u2265243),\n                    <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>\n                    (\u2265232) and\n                    <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                    (\u2265103) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a0.0355) within 2013\u20132017. Most isolates were from males (64.76%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a0.0329) and blood (67.48%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0&lt;\u00a0.0001), with substantial crude mortality (29.75%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a0.0488). Affected patients presented with other comorbidities: diabetes (\u226552), sepsis (\u226548), lung diseases (\u226539), kidney diseases (\u226532) etc. (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0&lt;\u00a0.0001). Resistance to fluconazole (44.29%), amphotericin B (15.46%), voriconazole (12.67%), caspofungin (3.48%) etc. were common (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a0.0059). Commonly used diagnostic tools included\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    (30.38%), Bruker\n                    <jats:styled-content style=\"fixed-case\">MALDI<\/jats:styled-content>\n                    \u2010\n                    <jats:styled-content style=\"fixed-case\">TOF MS<\/jats:styled-content>\n                    (14.00%), Vitek 2\n                    <jats:styled-content style=\"fixed-case\">YST ID<\/jats:styled-content>\n                    (11.93%),\n                    <jats:styled-content style=\"fixed-case\">AFLP<\/jats:styled-content>\n                    (11.55%) and\n                    <jats:styled-content style=\"fixed-case\">WGS<\/jats:styled-content>\n                    (10.04%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value\u00a0=\u00a0.002). Multidrug resistance, high attributable mortality and persistence are associated with\n                    <jats:italic>C. auris<\/jats:italic>\n                    infections. Two novel drugs,\n                    <jats:styled-content style=\"fixed-case\">SCY<\/jats:styled-content>\n                    \u2010078 and\n                    <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n                    \u20101598, are currently in the pipeline. Contact precautions, strict infection control, periodic surveillance and cleaning with chlorine\u2010based detergents, efficient, faster and cheaper detection tools are necessary for prevention, containment and early diagnosis of\n                    <jats:italic>C. auris<\/jats:italic>\n                    infections.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.578","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T01:02:47Z","timestamp":1516237367000},"source":"Crossref","is-referenced-by-count":268,"title":["<i>Candida auris<\/i>\n                    : A systematic review and meta\u2010analysis of current updates on an emerging multidrug\u2010resistant pathogen"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9508-984X","authenticated-orcid":false,"given":"John","family":"Osei Sekyere","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.05.016"},{"key":"e_1_2_17_3_1","unstructured":"Anonymous. (2017).Viamet's VT \u20101598 demonstrates potent activity against Candida auris and other life\u2010threatening fungal species. 1\u20132. Retrieved fromhttp:\/\/www.viamet.com\/docs\/PR_2017_6-5-17.pdf(accessed August 23 2017)."},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00485-17"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix460"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161486"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00435-17"},{"key":"e_1_2_17_8_1","unstructured":"Bishop L. Cummins M. Guy R. Hoffman P. Jeffery K. &Jeffery\u2010Smith A. \u2026Brown C.(2017).Guidance for the laboratory investigation management and infection prevention and control for cases of Candida auris. Retrieved fromwww.gov.uk\/phe(Accessed August 24 2017)."},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00189-16"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw147"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2016.07.008"},{"key":"e_1_2_17_12_1","unstructured":"CDC. (2017).Potent in vitro Activity of SCYNEXIS\u2019 SCY\u2010078 Against Multidrug\u2010Resistant Fungal Pathogen Candida auris Further Confirmed in an in vitro Study Conducted by the Centers for Disease Control and Prevention. Retrieved fromhttp:\/\/files.shareholder.com\/downloads\/AMDA-2NFFBT\/5043574146x0x942485\/06E785B0-3542-4512-A294-1FD3B0F5719A\/SCYX_News_2017_5_11_General_Releases.pdf(Accessed August 23 2017)."},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02248-12"},{"key":"e_1_2_17_14_1","unstructured":"Centers for Disease Control and Prevention. (2017a).Candida auris Case Count Updated: July 14 2017. Retrieved fromhttps:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/candida-auris.html Accessed 3 August 2017."},{"key":"e_1_2_17_15_1","unstructured":"Centers for Disease Control and Prevention. (2017b).Recommendations for Identification of Candida auris | Fungal Diseases | CDC. Retrieved fromhttps:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/recommendations.html(Accessed August 2 2017)."},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-014-3603-2"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1863-z"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-2027-1"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1910.130393"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006290"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2106.150270"},{"key":"e_1_2_17_22_1","unstructured":"European Centre for Disease Prevention and Control. (2016).Candida auris in healthcare settings Europe.Stock. ECDC 19 December 1\u20138. Retrieved fromhttps:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/Candida-in-healthcare-settings_19-Dec-2016.pdf(Accessed July 24 2017)."},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.11.009"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12519"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00218-17"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00940"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00367-15"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmmcr.0.T00018"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1609.09012"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1086\/597108"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00630-17"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.4582"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2016.11.004"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02396-16"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31079-0"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00319-11"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00791-17"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2007.131765"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02202-16"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12647"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.161497"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000419"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2013.11.007"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151840"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/13693786.2010.493563"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2016.00209"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178888"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.13169"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12918"},{"key":"e_1_2_17_51_1","article-title":"Environmental surfaces in healthcare facilities are a potential source for transmission of Candida auris and other Candida species","volume":"1","author":"Piedrahita C. T.","year":"2017","journal-title":"Infection Control and Hospital Epidemiology"},{"key":"e_1_2_17_52_1","first-page":"DC09","article-title":"A pilot study on carbapenemase detection: Do we see the same level of agreement as with the CLSI observations","volume":"10","author":"Pragasam A. K.","year":"2016","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.10.022"},{"key":"e_1_2_17_54_1","unstructured":"Public Health England. (2016).Candida auris identified in England \u2010 GOV.UK. Retrieved fromhttps:\/\/www.gov.uk\/government\/publications\/candida-auris-emergence-in-england\/candida-auris-identified-in-england(Accessed August 1 2017)."},{"key":"e_1_2_17_55_1","unstructured":"Public Health England.Candida auris within the United Kingdom: updated guidance published \u2010 GOV.UK. Retrieved fromhttps:\/\/www.gov.uk\/government\/publications\/candida-auris-emergence-in-england\/candida-auris-within-the-united-kingdom-updated-guidance-published(Accessed September 3 2017)."},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx034"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.riam.2016.11.002"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.4103\/0255-0857.108746"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S116229"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2008.00083.x"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.14745\/ccdr.v43i78a02"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.05.008"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.00722-15"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2016.07.003"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2302.161320"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06440-11"},{"key":"e_1_2_17_68_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.NAJ.0000515233.51795.b3"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6619a7"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6544e1"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-016-2864-9"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00921-17"}],"updated-by":[{"DOI":"10.1002\/mbo3.901","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000}}],"container-title":["MicrobiologyOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmbo3.578","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.578","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T06:06:50Z","timestamp":1695017210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,18]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1002\/mbo3.578"],"URL":"https:\/\/doi.org\/10.1002\/mbo3.578","archive":["Portico"],"relation":{},"ISSN":["2045-8827","2045-8827"],"issn-type":[{"value":"2045-8827","type":"print"},{"value":"2045-8827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,18]]},"article-number":"e00578"}}