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Elongation factor P (\n EF<\/jats:styled-content>\n \u2010P) is required for the stalled ribosome to continue translation and thus the absence of\n EF<\/jats:styled-content>\n \u2010P affects translation of the associated open reading frame. Here we report that\n EF<\/jats:styled-content>\n \u2010P controls translation of the\n mgtA<\/jats:italic>\n gene encoding a Mg\n 2+<\/jats:sup>\n \u2010transporting\n ATP<\/jats:styled-content>\n ase from the intracellualr pathogen\n Salmonella enterica<\/jats:italic>\n serovar Typhimurium.\n EF<\/jats:styled-content>\n \u2010P's effect on\n mgtA<\/jats:italic>\n translation is dependent on the 550th and 551st proline codons in the coding region and thus substitution of those proline codons eliminates\n EF<\/jats:styled-content>\n \u2010P\u2010mediated control of MgtA protein without affecting the Mg\n 2+<\/jats:sup>\n \u2010transporting activity of the\n mgtA<\/jats:italic>\n gene. The Pro550 and Pro551\u2010substituted\n mgtA<\/jats:italic>\n gene promotes\n Salmonella<\/jats:italic>\n 's intramacrophage survival and mouse virulence, suggesting that\n EF<\/jats:styled-content>\n \u2010P\u2010mediated translational control of the\n mgtA<\/jats:italic>\n gene is required for\n Salmonella<\/jats:italic>\n pathogenesis.\n <\/jats:p>","DOI":"10.1002\/mbo3.680","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T08:46:38Z","timestamp":1530089198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Elongation factor P controls translation of the\n mgtA<\/i>\n gene encoding a Mg\n 2+<\/sup>\n transporter during\n Salmonella<\/i>\n infection"],"prefix":"10.1002","volume":"8","author":[{"given":"Eunna","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering and Graduate School of Biotechnology College of Life Sciences Kyung Hee University Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daesil","family":"Nam","sequence":"additional","affiliation":[{"name":"Division of Microbiology Department of Molecular Cell Biology Samsung Biomedical Research Institute Sungkyunkwan University School of Medicine Suwon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongjoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Microbial Pathogenesis Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Molecular Bioscience College of Biomedical Science Kangwon National University Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Shin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Molecular Bioscience College of Biomedical Science Kangwon National University Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5078-1974","authenticated-orcid":false,"given":"Eun\u2010Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Graduate School of Biotechnology College of Life Sciences Kyung Hee University Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.05.030"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175800"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.17.5376"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep42098"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705437114"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.043"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.120163297"},{"key":"e_1_2_7_9_1","volume-title":"Advanced bacterial genetics","author":"Davis R. 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