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Carbapenem\u2010resistant bacteria are increasingly being isolated from healthcare facilities; however, little is known about their distribution or prevalence in the environment, especially in the United States, where their distribution in water environments from the West Coast has not been studied before. The aim of this study was to determine the prevalence of carbapenem\u2010resistant bacteria and carbapenemase genes in water bodies from the Los Angeles area (California,\n                    <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content>\n                    ). All samples that were analyzed contained carbapenem\u2010resistant bacteria with a frequency of between 0.1 and 324 carbapenem\u2010resistant cfu per 100\u00a0mls of water. We identified 76 carbapenem\u2010resistant or \u2010intermediate isolates, most of which were also resistant to noncarbapenem antibiotics, as different strains of\n                    <jats:italic>Enterobacter asburiae<\/jats:italic>\n                    ,\n                    <jats:italic>Aeromonas veronii<\/jats:italic>\n                    ,\n                    <jats:italic>Cupriavidus gilardii<\/jats:italic>\n                    ,\n                    <jats:italic>Pseudomonas,<\/jats:italic>\n                    and\n                    <jats:italic>Stenotrophomonas<\/jats:italic>\n                    species. Of them, 52 isolates were carbapenemase\u2010producers. Furthermore,\n                    <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\n                    and sequence analysis to identify the carbapenemase gene of these carbapenemase\u2010producing isolates revealed that all\n                    <jats:italic>Enterobacter asburiae<\/jats:italic>\n                    isolates had a\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:sub>IMI<\/jats:sub>\n                    <\/jats:styled-content>\n                    <jats:sub>\u20102<\/jats:sub>\n                    gene 100% identical to the reference sequence, and all\n                    <jats:italic>Stenotrophomonas maltophlia<\/jats:italic>\n                    isolates had a\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>L1<\/jats:sub>\n                    gene 83%\u201399% identical to the reference\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>L1<\/jats:sub>\n                    . Our findings indicate that water environments in Southern California are an important reservoir of bacteria\u2010resistant to carbapenems and other antibiotics, including bacteria carrying intrinsic and acquired carbapenemase genes.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.692","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T04:21:17Z","timestamp":1531196477000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Prevalence and characterization of carbapenem\u2010resistant bacteria in water bodies in the Los Angeles\u2013Southern California area"],"prefix":"10.1002","volume":"8","author":[{"given":"Dana E.","family":"Harmon","sequence":"first","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo A.","family":"Miranda","sequence":"additional","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"McCarley","sequence":"additional","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Eshaghian","sequence":"additional","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Carlson","sequence":"additional","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-5180","authenticated-orcid":false,"given":"Cristian","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Biology California State University Northridge  Northridge California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0807.010264"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1102.030684"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.413-419.2001"},{"key":"e_1_2_8_6_1","volume-title":"Bergey's manual of determinative bacteriology, 9th Ed","author":"Bergey D. 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