{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:25Z","timestamp":1786978345773,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antimicrobial resistance remains a global issue, hindering the control of bacterial infections. This study examined the antimicrobial properties of 2,3\u2010N,N\u2010diphenyl quinoxaline derivatives against Gram\u2010positive, Gram\u2010negative, and Mycobacterium species. Two quinoxaline derivatives (compounds 25 and 31) exhibited significant activity against most strains of\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ,\n                    <jats:italic>Enterococcus faecium<\/jats:italic>\n                    , and\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    tested, with MIC values ranging from 0.25 to 1\u2009mg\/L. These compounds also showed effective antibacterial activity against methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    (MRSA) and vancomycin\u2010resistant\n                    <jats:italic>E. faecium<\/jats:italic>\n                    \/\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    (VRE) strains. They demonstrated comparable or superior activity to four current antibiotics (vancomycin, teicoplanin, daptomycin, and linezolid) against a wide range of clinically relevant isolates. Additionally, they were more effective in preventing\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    biofilm formation compared to several other antibiotics. In summary, these two quinoxaline derivatives have potential as new antibacterial agents.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70011","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T05:43:04Z","timestamp":1733982184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Compounds Containing 2,3\u2010Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin\u2010Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    ,\n                    <i>Enterococcus faecalis<\/i>\n                    , and Their Biofilms"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-1293","authenticated-orcid":false,"given":"Gilda","family":"Padalino","sequence":"first","affiliation":[{"name":"Swansea University Medical School  Swansea UK"},{"name":"Department of Life Sciences (DLS) Aberystwyth University  Aberystwyth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Duggan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis A. 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