{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T11:50:57Z","timestamp":1769773857084,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T00:00:00Z","timestamp":1751155200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    is a clinically significant non\u2010albicans species that has shown increasing azole resistance globally. Despite its growing clinical importance, genotypic and epidemiological data from East Asia, particularly Korea, remain limited. This study aimed to expand the global understanding of\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    population structure by genotyping clinical isolates from Korea and identifying novel sequence types. Thirty\u2010four clinical isolates collected from tertiary hospitals across Korea between 2012 and 2019 were analyzed using multilocus sequence typing (MLST) based on six housekeeping genes (ICL1, MDR1, SAPT2, SAPT4, XYR1, and ZWF1). A total of 21 diploid sequence types (DSTs) were identified, including three novel DSTs (1418, 1419, and 1420) not previously recorded in the MLST central database. Notably, DST844 (CTR\u201019 isolate) exhibited elevated minimum inhibitory concentration (MIC) to fluconazole, suggesting a potential novel resistance phenotype. Phylogenetic and goeBURST analyses revealed 11 distinct clonal complexes (CCs), some of which showed similarity to Chinese and Brazilian lineages, indicating cross\u2010regional evolutionary links. These findings enhance the global MLST data set, provide new insights into the molecular epidemiology of\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    in Korea, and highlight the need for continued antifungal resistance surveillance, particularly for emerging DSTs.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70024","type":"journal-article","created":{"date-parts":[[2025,7,13]],"date-time":"2025-07-13T13:03:47Z","timestamp":1752411827000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genotypic Analysis of\n                    <i>Candida tropicalis<\/i>\n                    Clinical Isolates From Korea via Multilocus Sequence Typing"],"prefix":"10.1002","volume":"14","author":[{"given":"Hye\u2010won","family":"Park","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science, College of Health Sciences Yonsei University Wonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon\u2010Sung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Inje University Haeundae Paik Hospital Inje University College of Medicine Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyoung","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Ho","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"},{"name":"Korea Mycobacterium Resource Center (KMRC), Department of Research and Development The Korean Institute of Tuberculosis, Osong  Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Development DreamDX Inc. Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwangmin","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"},{"name":"Next\u2010Generation Industrial Field\u2010Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Geon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"},{"name":"Next\u2010Generation Industrial Field\u2010Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biomedical Laboratory Science Masan University Changwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunghyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"},{"name":"Next\u2010Generation Industrial Field\u2010Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3517-2243","authenticated-orcid":false,"given":"Jungho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Science, College of Health Sciences Catholic University of Pusan Busan Republic of Korea"},{"name":"Next\u2010Generation Industrial Field\u2010Based Specialist Program for Molecular Diagnostics, Brain Busan 21 Plus Project, Graduate School Catholic University of Pusan Busan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.587278"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myz124"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7070577"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanmic.2024.07.012"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004404"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.105.048975"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08064"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-03176-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13483"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2010.04.006"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44825-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msj030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8090896"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.606976"},{"issue":"3","key":"e_1_2_10_16_1","first-page":"281","article-title":"Frequency, Clinical Presentation and Microbiological Spectrum of Candidemiain a Tertiary Care Center in Karachi, Pakistan","volume":"64","author":"Kumar S.","year":"2014","journal-title":"JPMA. 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