{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:30:05Z","timestamp":1780677005206,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Although the COVID\u201019 pandemic has created many challenges and negative impacts around the world, some of which will persist into the future, its technological challenge has created a unique opportunity in a globalized world. It is a rare event that almost all of humanity to be directed towards a single goal and to try to produce solutions, but the necessity of a similar global action in the future has begun to enter the agenda again. The predictions made on the basis of countries and institutions against the possibility of a pandemic, which is defined as Disease X, are shaped by the experience of the COVID\u201019 pandemic. Technologically, one of the know\u2010how we have gained in this pandemic is the performance of IVD and test systems in terms of quality and quantity. A comprehensive analysis of the products produced by combining biotechnology with different strategies has not been conducted. In this context, we have analyzed the technical preferences, limitations, and other performance parameters of IVDs and test kits that could be developed against a future Disease X. The performance parameters of 2,882 biotechnological products listed for use in the European Union have been analyzed, and areas that could be targeted for increased effectiveness have been identified. Our study is the first of its kind in this field and can serve as a guide for those who want to work on detection methods, diagnostics, and novel technologies for deployment in future pandemics.<\/jats:p>","DOI":"10.1002\/mbo3.70042","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T11:44:26Z","timestamp":1754307866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Biotechnological Preparedness for Novel Pandemics: Diagnostic Performance of IVDS Against SARS\u2010CoV\u20102"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5331-7253","authenticated-orcid":false,"given":"Murat","family":"Kavruk","sequence":"first","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Department of Molecular Biology and Genetics, Faculty of Arts &amp; Sciences \u0130stanbul Ayd\u0131n University \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-6325","authenticated-orcid":false,"given":"Meltem","family":"Ercan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Genetics, Faculty of Medicine, Department of Molecular Biology and Genetics, Faculty of Arts &amp; Sciences \u0130stanbul Ayd\u0131n University \u0130stanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-2933","authenticated-orcid":false,"given":"Bar\u0131\u015f Ata","family":"Borsa","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology (IFM) Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-5990","authenticated-orcid":false,"given":"Veli Cengiz","family":"\u00d6zalp","sequence":"additional","affiliation":[{"name":"Deparment of Medical Biology, Faculty of Medicine At\u0131l\u0131m University Ankara T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6308-8087","authenticated-orcid":false,"given":"Frank J.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Physics, Chemistry and Biology (IFM) Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Department of Bioengineering and Biosciences, TECNUN Navarra University  Spain"},{"name":"IKERBASQUE, Basque Foundation for Science Bilbao Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.06.02.131144"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.INTIMP.2021.108144"},{"key":"e_1_2_10_4_1","unstructured":"Clarivate.2021.Citation Topics.https:\/\/incites.help.clarivate.com\/Content\/Research-Areas\/citation-topics.htm."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013705"},{"key":"e_1_2_10_6_1","unstructured":"FDA.2023a.COVID\u201019 Emergency Use Authorizations for Medical Devices | FDA.https:\/\/www.fda.gov\/medical-devices\/emergency-use-authorizations-medical-devices\/covid-19-emergency-use-authorizations-medical-devices."},{"key":"e_1_2_10_7_1","unstructured":"FDA.2023b.COVID\u201019 Test Basics | FDA.https:\/\/www.fda.gov\/consumers\/consumer-updates\/covid-19-test-basics."},{"key":"e_1_2_10_8_1","unstructured":"FDA.2025.COVID\u201019 Tests Granted Traditional Marketing Authorization by the FDA | FDA.https:\/\/www.fda.gov\/medical-devices\/coronavirus-covid-19-and-medical-devices\/covid-19-tests-granted-traditional-marketing-authorization-fda."},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOSX.2022.100289"},{"key":"e_1_2_10_10_1","unstructured":"JRC.2021.JRC COVID\u201019 IVD Devices and Test Methods Dataset \u2013 Data Europa EU.https:\/\/data.europa.eu\/data\/datasets\/jrc-covid-19-ivd-devices-and-test-methods-dataset?locale=en."},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOS.2022.114109"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4274\/atfm.galenos.2023.24855"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRIP.2020.100111"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJRAD.2020.108961"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.TRAC.2024.118131"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","unstructured":"Lucia C. 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