{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:28:16Z","timestamp":1765376896131,"version":"3.46.0"},"reference-count":86,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    is widely recognized as a multidrug\u2010resistant pathogen, although most public genome datasets are biased toward hospital\u2010derived isolates. Little is known about\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates from healthy individuals in the community. This study analyzed genome sequences from nine\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates obtained from the upper respiratory tract of the indigenous Orang Asli in their rural community in Peninsular Malaysia. Genomic analysis revealed genetic diversity, including three new Pasteur sequence types (STs) and six novel Oxford STs. One isolate,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    19064, belonged to Global Clone 8 (GC8), a lineage linked to clinical infections. Core genome phylogeny showed these community isolates interspersed with clinical isolates from a nearby hospital, indicating potential pathogenicity under suitable conditions. All isolates carried intrinsic\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA\u201051\u2010like<\/jats:sub>\n                    carbapenemase and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>ADC<\/jats:sub>\n                    cephalosporinase genes but remained susceptible to meropenem. Two isolates,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    19053 and 19062, were tetracycline resistant but minocycline susceptible, and harbored the\n                    <jats:italic>tet(39)\u2013tetR<\/jats:italic>\n                    gene pair within a mobile p\n                    <jats:italic>dif<\/jats:italic>\n                    module on distinct Rep_3\u2010type plasmids. Only one isolate,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    19055, is plasmid\u2010free; the rest mainly harbored cryptic plasmids, often containing identifiable p\n                    <jats:italic>dif<\/jats:italic>\n                    modules. These findings highlight the clinical relevance of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    strains residing in healthy individuals, particularly in isolated communities that are seldom accessible to public health. Despite their remote origins, these isolates possess virulence factors and resistance genes similar to those in hospital settings. This underscores the importance of genomic surveillance of commensal pathogens, as exploring these less\u2010studied isolates can yield insights into broader epidemiological trends and guide future public health strategies.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70073","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:35:20Z","timestamp":1760697320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Road Less Traveled: Exploring the Genomic Characteristics and Antimicrobial Resistance Potential of\n                    <i>Acinetobacter baumannii<\/i>\n                    From the Indigenous Orang Asli Community in Peninsular Malaysia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2239-2004","authenticated-orcid":false,"given":"Soo\u2010Sum","family":"Lean","sequence":"first","affiliation":[{"name":"Faculty of Medicine 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