{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:58:03Z","timestamp":1791622683025,"version":"4.3.4"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Urinary tract infection (UTI) is the most common bacterial infection globally and is often treated empirically in community settings, contributing to antimicrobial resistance. Uropathogenic\n                      <jats:italic>E. coli<\/jats:italic>\n                      (UPEC) is the leading cause of community\u2010acquired UTIs (CA\u2010UTIs), yet data on its clinical and molecular characteristics remain limited. To investigate the clinical and microbiological features of CA\u2010UTIs, focusing on antimicrobial resistance, phylogenetic groups, virulence genes, and clonal profiles. Randomly selected\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates from CA\u2010UTI cases underwent antimicrobial susceptibility testing. PCR was used to detect \u03b2\u2010lactamase genes, phylogenetic groups, and key virulence factors. MLST was used for clonal typing. Clinical and demographic data were obtained through structured interviews. Among 98 CA\u2010UPEC isolates, most were from female patients (95.9%), median age 48 years. High resistance was observed to ampicillin (50.0%), trimethoprim\u2010sulfamethoxazole (34.7%), and fluoroquinolones (33.7%), while resistance to nitrofurantoin and fosfomycin was low (1%). Multidrug resistant (MDR) strains accounted for 24.5%, with 6.1% being ESBL producers, all harboring\n                      <jats:italic>bla<\/jats:italic>\n                      <jats:sub>CTX\u2010M\u2010type<\/jats:sub>\n                      genes. Phylogenetic group B2 (48.0%) carried the most virulence genes, while group A had more MDR strains. Common virulence genes included\n                      <jats:italic>fimH<\/jats:italic>\n                      (95.9%),\n                      <jats:italic>PAI<\/jats:italic>\n                      IV\n                      <jats:sub>536<\/jats:sub>\n                      (77.6%), and\n                      <jats:italic>fyuA<\/jats:italic>\n                      (76.5%). Genes\n                      <jats:italic>aer<\/jats:italic>\n                      , and\n                      <jats:italic>iutA<\/jats:italic>\n                      were linked to MDR, while\n                      <jats:italic>papC, sfa, hlyA<\/jats:italic>\n                      were more common in non\u2010MDR isolates. ST1193, a high\u2010risk clone, was the most prevalent (25.0%), found only among MDR strains. ST73 and ST127 were associated with multiple virulence genes but were non\u2010MDR. Nitrofurantoin and fosfomycin remain effective options for CA\u2010UTIs. Continuous surveillance is vital to guide treatment and track resistance trends.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mbo3.70074","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:25:26Z","timestamp":1761110726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["High Rates of Antimicrobial Resistance and Emergence of High\u2010Risk Clones in Community\u2010Acquired Uropathogenic\n                    <i>Escherichia coli<\/i>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-0610","authenticated-orcid":false,"given":"V\u00edvian Santos","family":"Galv\u00e3o","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pharmacy, Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"},{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6675-4217","authenticated-orcid":false,"given":"Adriano","family":"Souza Santos Monteiro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-9852","authenticated-orcid":false,"given":"Jo\u00e3o Lucas Pinheiro","family":"Leite","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmacy, Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"},{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0430-3521","authenticated-orcid":false,"given":"Isabela Oliveira","family":"Sousa","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Microbiology Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5320-892X","authenticated-orcid":false,"given":"Soraia Machado","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-2658","authenticated-orcid":false,"given":"Joice Neves","family":"Reis","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pharmacy, Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"},{"name":"Faculty of Pharmacy Federal University of Bahia Salvador Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-56254-4"},{"issue":"11","key":"e_1_2_11_3_1","first-page":"050","article-title":"Antimicrobial Susceptibility of Uropathogens and Prescribing Patterns in Hospital\u2010 and Community\u2010Acquired Urinary Tract Infections in a Tertiary Care Hospital","volume":"10","author":"Achukutty T.","year":"2020","journal-title":"Journal of Applied Pharmaceutical Science"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13353-022-00683-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S226215"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-29882-0_11"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2022.106667"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03104-13"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038248"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/681473"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimc.2015.11.017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00243"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1758-2229.12019"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.14713"},{"key":"e_1_2_11_15_1","unstructured":"CLSI.Performance Standards for Antimicrobial Susceptibility Testing.33rd Ed.CLSI Supplement M100. 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