{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:40:44Z","timestamp":1769636444774,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hexachlorocyclohexane (HCH) was extensively used as a pesticide until the 1990s. It was synthesized by benzene photochlorination, resulting in a mixture of stereoisomers, which included \u03b1\u2010, \u03b2\u2010, \u03b3\u2010, and \u03b4\u2010HCH, among others. It was later discovered that only the \u03b3\u2010HCH isomer (also called lindane) had insecticidal properties, so it began to be purified from this mixture, while the remaining HCH isomers (representing around 85%\u201390% of industrial HCH production) were disposed of in dumpsites, generating environmental issues. Several works have studied microbial\u2010driven biodegradation and physiological responses to \u03b3\u2010HCH, but information concerning the other isomers is scarce. Since previous research showed that the cyanobacterium\n                    <jats:italic>Anabaena sp<\/jats:italic>\n                    . PCC 7120 is effective at removing lindane; this study focused on its responses to the \u03b1\u2010, \u03b2\u2010, and \u03b4\u2010HCH isomers. The results showed that\n                    <jats:italic>Anabaena<\/jats:italic>\n                    tolerates \u03b1\u2010 and \u03b3\u2010HCH well, with little impact on growth, while \u03b2\u2010 and \u03b4\u2010HCH are more poorly tolerated and negatively affect growth and cell physiology. It was also found that, in the presence of\n                    <jats:italic>Anabaena<\/jats:italic>\n                    sp. PCC 7120, both \u03b1\u2010 and \u03b3\u2010HCH are completely eliminated from supernatants while \u03b2\u2010 and \u03b4\u2010HCH are partially eliminated. Additionally, the\n                    <jats:italic>linC<\/jats:italic>\n                    gene was found to be expressed at twice the normal level in the presence of \u03b1\u2010 and \u03b3\u2010HCH at 2\u2009mg\/mL. Overall, this study reveals how\n                    <jats:italic>Anabaena<\/jats:italic>\n                    responds to key HCH isomers found in contaminated sites and supports its potential use in bioremediation.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70105","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T11:41:01Z","timestamp":1764675661000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights on\n                    <i>Anabaena<\/i>\n                    sp. PCC 7120 Responses to HCH Isomers: Tolerance, Degradation, and Dynamics on Potential\n                    <i>lin<\/i>\n                    Genes Expression"],"prefix":"10.1002","volume":"14","author":[{"given":"Jorge","family":"Gu\u00edo","sequence":"first","affiliation":[{"name":"Department of Biochemistry &amp; Molecular and Cellular Biology University of Zaragoza Zaragoza Spain"},{"name":"Institute for Biocomputation and Physics of Complex Systems (BIFI) Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Peleato","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular and Cellular Biology University of Zaragoza Zaragoza Spain"},{"name":"Institute for Biocomputation and Physics of Complex Systems (BIFI) Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6435-3540","authenticated-orcid":false,"given":"Emma","family":"Sevilla","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular and Cellular Biology University of Zaragoza Zaragoza Spain"},{"name":"Institute for Biocomputation and Physics of Complex Systems (BIFI) Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02979709"},{"key":"e_1_2_10_3_1","volume-title":"Patty's Industrial Hygiene and Toxicology: General Principles","author":"Clayton G. D.","year":"1991"},{"key":"e_1_2_10_4_1","first-page":"38","volume-title":"Chemistry and Biochemistry of Plant Pigments","author":"Davies B. 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