{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:58:52Z","timestamp":1773255532694,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    is a fungal commensal of humans that often causes mucosal infections in otherwise healthy individuals and also serious infections in immunocompromised patients. The capacity of this fungus to colonize and cause disease relies on its ability to grow within the host, adapting to various nutrient restrictions and physicochemical conditions. The presence of alternative carbon sources, such as the lactate produced by the local microbiota, influences\n                    <jats:italic>C. albicans<\/jats:italic>\n                    antifungal drug resistance and immune evasion. In this study, we used genome\u2010wide transcriptomic analysis to investigate the effect of lactate exposure upon metabolic rewiring. We provide evidence that\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cells respond to growth in the presence of lactate at pH 5 by regulating genes encoding micronutrient transporters, notably iron transporters. More specifically, lactate triggers the downregulation of genes on the reductive iron uptake pathway, inferring a diminished requirement for high\u2010affinity iron uptake. This is supported by the observation that lactate promotes the intracellular accumulation of iron by\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cells. Lactate even enhances the growth of iron\u2010transport defective\n                    <jats:italic>C. albicans<\/jats:italic>\n                    cells under iron\u2010limited conditions. Lactate is known to activate protein kinase A (PKA) signaling. However, lactate\u2010induced iron assimilation is PKA\u2010independent. This study provides new insights into the role of lactate in iron homeostasis\u2014two important factors that promote\n                    <jats:italic>C. albicans<\/jats:italic>\n                    virulence in the mammalian host, where nutritional immunity is a key antimicrobial strategy.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70167","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:43:13Z","timestamp":1765885393000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lactic Acid Influences Iron Assimilation by a Fungal Pathogen via the Iron Reductive Uptake Pathway"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-5575","authenticated-orcid":false,"given":"Alexandra","family":"Gomes\u2010Gon\u00e7alves","sequence":"first","affiliation":[{"name":"CBMA University of Minho Braga Portugal"},{"name":"Institute of Science and Innovation for Bio\u2010Sustainability University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Van Genechten","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology K.U. Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia","family":"Ata\u00edde","sequence":"additional","affiliation":[{"name":"CBMA University of Minho Braga Portugal"},{"name":"Institute of Science and Innovation for Bio\u2010Sustainability University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia","family":"Barata\u2010Antunes","sequence":"additional","affiliation":[{"name":"CBMA University of Minho Braga Portugal"},{"name":"Institute of Science and Innovation for Bio\u2010Sustainability University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faezeh","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"CBMA University of Minho Braga Portugal"},{"name":"Institute of Science and Innovation for Bio\u2010Sustainability University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida","family":"Casal","sequence":"additional","affiliation":[{"name":"CBMA University of Minho Braga Portugal"},{"name":"Institute of Science and Innovation for Bio\u2010Sustainability University of Minho Braga Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Instituto Superior T\u00e9cnico Universidade de Lisboa Lisbon Portugal"},{"name":"iBB \u2013 Institute for Bioengineering and Biosciences, Associate Laboratory Institute for Health and Bioeconomy \u2010 i4HB Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaqu\u00edn","family":"Ari\u00f1o","sequence":"additional","affiliation":[{"name":"Dept. de Bioqu\u00edmica i Biologia Molecular, Institut de Biotecnolog\u00eda i Biomedicina Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair J. 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