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This study investigated 29\n                    <jats:italic>Bacillus<\/jats:italic>\n                    and\n                    <jats:italic>Paenibacillus<\/jats:italic>\n                    isolates from the soil for antimicrobial activity against multidrug\u2010resistant clinical pathogens, including methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA) and carbapenem\u2010resistant Enterobacterales (CRE). In both agar\u2010 and broth\u2010based antimicrobial assays,\n                    <jats:italic>Paenibacillus profundus<\/jats:italic>\n                    strains 7.5 and M4.5 exhibited potent broad\u2010spectrum activity, including significant inhibition of many CREs. Species identification was performed through 16S rRNA sequencing, and genome mining of three producer strains using antiSMASH revealed biosynthetic gene clusters associated with a variety of nonribosomal peptide synthetases (NRPSs), polyketide synthases (PKSs), and ribosomally synthesized and post\u2010translationally modified peptides (RiPPs). While many of these clusters were not associated with known antimicrobial compounds, several of them displayed high similarity to known compounds such as polymyxin B, paenilan, colistin, and paenibacterin. These findings reinforce numerous previous studies highlighting the potential of soil\u2010derived\n                    <jats:italic>Bacillus<\/jats:italic>\n                    and\n                    <jats:italic>Paenibacillus<\/jats:italic>\n                    species as valuable sources of novel antimicrobials to address the global antibiotic resistance crisis.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70179","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:21:03Z","timestamp":1765513263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Various\n                    <i>Bacillus<\/i>\n                    and\n                    <i>Paenibacillus<\/i>\n                    Spp. Isolated From Soil Produce Compounds With Potent Antimicrobial Activity Against Clinically Relevant Pathogens"],"prefix":"10.1002","volume":"14","author":[{"given":"Michael","family":"Moran","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Biology Brigham Young University Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hogan","family":"Turner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology Brigham Young University Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Yanchar","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology Brigham Young University Provo Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Preece","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology Brigham Young University Provo Utah 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