{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:20:58Z","timestamp":1787732458569,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fungal infections pose a severe health risk, particularly in immunocompromised individuals, with\n                    <jats:italic>Candida<\/jats:italic>\n                    species being a leading cause of bloodstream infections. The rise of non\u2010\n                    <jats:italic>albicans Candida<\/jats:italic>\n                    (NAC) infections, accounting for 35%\u201365% of candidemia cases, underscores the urgent need for novel antifungal strategies. Current treatments, including echinocandins and azoles, are increasingly challenged by drug\u2010resistant strains. This study evaluated the antifungal efficacy of three clinically approved histone deacetylase inhibitors (HDACi)\u2014Vorinostat, Romidepsin, and Tucidinostat\u2014along with the HDAC6\/8\u2010selective inhibitor MC1568, alone and in combination with Fluconazole. The Fluconazole\/MC1568 combination exhibited significant synergistic effects, reducing biofilm formation and enhancing antifungal activity, particularly against\n                    <jats:italic>C. guillermondii<\/jats:italic>\n                    ,\n                    <jats:italic>C. lusitaniae<\/jats:italic>\n                    , and\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    . In\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    larvae, this combination increased survival by 70% in\n                    <jats:italic>C. tropicalis<\/jats:italic>\n                    infections. When tested in human retinal pigment epithelium (RPE) cells, three different MC1568\/Fluconazole combinations displayed low toxicity. These findings highlight the potential of the HDAC6\/8 inhibitor MC1568 as adjunct therapy to combat NAC infections, warranting further research to optimize antifungal efficacy while minimizing toxicity.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70188","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:37:18Z","timestamp":1783481838000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of the HDAC6\/8 Inhibitor MC1568, Alone and in Combination With Fluconazole, in Non\u2010\n                    <i>Albicans Candida<\/i>\n                    Species Infections"],"prefix":"10.1002","volume":"15","author":[{"given":"Andrea","family":"Giammarino","sequence":"first","affiliation":[{"name":"Department of Public Health and Infectious Diseases Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Lambona","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Raucci","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Macr\u00ec","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Iuzzolino","sequence":"additional","affiliation":[{"name":"IBPM Institute of Molecular Biology and Pathology CNR National Research Council of Italy Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Trisciuoglio","sequence":"additional","affiliation":[{"name":"IBPM Institute of Molecular Biology and Pathology CNR National Research Council of Italy Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Giusiano","sequence":"additional","affiliation":[{"name":"Departamento de Micolog\u00eda, Instituto de Medicina Regional Universidad Nacional del Nordeste  Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-5587","authenticated-orcid":false,"given":"Letizia","family":"Angiolella","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Diseases Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Mai","sequence":"additional","affiliation":[{"name":"Department of Drug Chemistry and Technologies Sapienza University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts, CLSI M27 A4","author":"Alexander B. 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