{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:35:01Z","timestamp":1790422501139,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Shewanella algae<\/jats:italic>\n                    , a marine\u2010origin opportunistic pathogen, has shown a significant increase in non\u2010coastal infections, yet its environmental adaptability and synergistic pathogenic mechanisms with Epstein\u2010Barr virus (EBV) coinfection remain unclear. This study reports a clinical case of\n                    <jats:italic>S. algae<\/jats:italic>\n                    bloodstream infection complicated by EBV reactivation leading to septic shock in Sichuan Province, China, and elucidates the molecular mechanisms through genomic analysis. Pathogen identification was performed via blood culture, antibiotic susceptibility testing, and genomic annotation. The strain harbored resistance genes (\n                    <jats:italic>acrB<\/jats:italic>\n                    ,\n                    <jats:italic>tolC<\/jats:italic>\n                    ,\n                    <jats:italic>tet(35)<\/jats:italic>\n                    ,\n                    <jats:italic>golS<\/jats:italic>\n                    ) and virulence factors (\n                    <jats:italic>bplL<\/jats:italic>\n                    \/\n                    <jats:italic>bplF<\/jats:italic>\n                    ,\n                    <jats:italic>clpC<\/jats:italic>\n                    \/\n                    <jats:italic>clpP<\/jats:italic>\n                    ,\n                    <jats:italic>tonB<\/jats:italic>\n                    ). Phylogenetic analysis indicated the highest genetic affinity to freshwater\u2010derived\n                    <jats:italic>Shewanella chilikensis<\/jats:italic>\n                    , while pan\u2010genome analysis identified 1412 unique genes, including transmembrane transporters and carbohydrate\u2010active enzyme genes, suggesting freshwater adaptive evolution. Metagenomic next\u2010generation sequencing (mNGS) detected a high EBV load. The patient succumbed to multi\u2010organ failure. This study reveals that\n                    <jats:italic>S. algae<\/jats:italic>\n                    may evolve freshwater adaptability to cause inland infections, and EBV coinfection accelerates septic shock through immunosuppression and inflammatory cascades. Genomic analysis provides critical insights for precision diagnosis and treatment of polymicrobial infections.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70221","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:43:15Z","timestamp":1768898595000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Septic Shock Caused by Coinfection of\n                    <i>Shewanella algae<\/i>\n                    Bloodstream Infection and Epstein\u2010Barr Virus: Clinical Characteristics and Genomic Analysis"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8610-5042","authenticated-orcid":false,"given":"Jianmei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Chongzhou People's Hospital Chongzhou 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