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Oral samples from 62 individuals (38 SARS\u2010CoV\u20102 positive, 24 negative) were analyzed using 16S rRNA sequencing, comparing diversity and taxa by infection and symptoms. Longitudinal data from 11 participants assessed microbiome changes as the infection resolved over time. To assess the impact of vaccination, we further examined 68 consistently SARS\u2010CoV\u20102\u2013negative individuals with paired samples collected before and after vaccination. SARS\u2010CoV\u20102 infection was not significantly associated with alpha diversity, while beta diversity showed a non\u2010significant but marginal trend (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.051).\n                    <jats:italic>Prevotella nanceiensis<\/jats:italic>\n                    was consistently depleted in infected individuals, even after excluding recent antibiotic users, suggesting a reproducible association with infection status rather than a diagnostic marker. Among infected participants, mucosa\u2010related symptoms were associated with lower\n                    <jats:italic>Veillonella parvula<\/jats:italic>\n                    abundance. Longitudinal data revealed stable microbiome profiles with slightly reduced variance in alpha diversity following viral clearance. In contrast, COVID\u201019 vaccination in consistently negative individuals was associated with significant increases in Shannon (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.050) and Simpson diversity (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017), indicating greater evenness without expansion of richness. Beta diversity analyses showed vaccination\u2010related shifts in community composition (PERMANOVA\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.026), with increases in\n                    <jats:italic>Treponema<\/jats:italic>\n                    ,\n                    <jats:italic>Campylobacter<\/jats:italic>\n                    ,\n                    <jats:italic>Oribacterium<\/jats:italic>\n                    , and\n                    <jats:italic>Selenomonas<\/jats:italic>\n                    , and a decrease in\n                    <jats:italic>Haemophilus<\/jats:italic>\n                    . The oral microbiome of Hispanics with mild SARS\u2010CoV\u20102 infection appeared resilient, with only subtle taxonomic alterations. In contrast, COVID\u201019 vaccination was associated with short\u2010term increases in diversity and compositional shifts, highlighting its influence on oral microbial ecology.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70310","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:35:03Z","timestamp":1778124903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Microbiome Resilience During SARS\u2010CoV\u20102 Infection and Diversity Shifts After COVID\u201019 Vaccination in a Hispanic Population"],"prefix":"10.1002","volume":"15","author":[{"given":"Daniela","family":"Vargas\u2010Robles","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean L.","family":"Santos Agrait","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Puerto Rico, School of Medicine, Medical Sciences Campus San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaleniz","family":"Su\u00e1rez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"},{"name":"Comprehensive Cancer Center, University of Puerto Rico Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anelisse","family":"Dominicci\u2010Maura","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.","family":"Sariol","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"},{"name":"Unit of Comparative Medicine, Department of Medicine University of Puerto Rico\u2010Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Zorrilla","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Puerto Rico, School of Medicine, Medical Sciences Campus San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Romaguera","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Puerto Rico, School of Medicine, Medical Sciences Campus San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Godoy\u2010Vitorino","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Puerto Rico, School of Medicine Medical Sciences Campus  San Juan Puerto Rico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118445112.stat07841"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104731"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-81864-3"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2010.30"},{"key":"e_1_2_11_6_1","unstructured":"Bisanz J. 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