{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:47:57Z","timestamp":1782470877920,"version":"3.54.5"},"reference-count":97,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) is one of the most common types of cancer worldwide, and the gut microbiome plays a crucial role in its development. In the study, we examine the variation in gut microbial community composition among individuals diagnosed with CRC based on human fecal samples. A systematic search of online databases, including MEDLINE (PubMed), Web of Science, Embase, and Scopus up to March 2026, following the requirements outlined in the PRISMA guideline. The search strategy was based on a combination of keywords, including \u201ccolorectal cancer,\u201d \u201cgut microbiome\u201d, and \u201cfeces.\u201d The study analyzed 43 research articles on colorectal cancer microbiome. Most investigations utilized culture\u2010independent techniques, revealing variations in microbial profiles between colorectal cancer cases and healthy controls.\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    and\n                    <jats:italic>Porphyromonas<\/jats:italic>\n                    emerged as potential colorectal cancer biomarkers, while multi\u2010bacteria predictive models showed promise in enhancing colorectal cancer detection sensitivity and specificity. In this review, we will explore how advanced sequencing techniques have the potential to complement current non\u2010invasive methods for early diagnosis and prevention of colorectal cancer. This includes conducting studies with robust statistical power and consistent, replicable methodologies, taking into consideration host factors, and performing external validation of predictive models.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70326","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:21:08Z","timestamp":1781752868000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fecal Microbiome Alterations in Colorectal Cancer: A Systematic Review of Compositional Changes and Microbial Biomarkers"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7699-7765","authenticated-orcid":false,"given":"Parvin","family":"Askari","sequence":"first","affiliation":[{"name":"Infectious Diseases Research Center Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Dashtbin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Iran University of Medical Sciences Tehran Iran"},{"name":"Microbial Biotechnology Research Centre Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4584-2327","authenticated-orcid":false,"given":"Tahereh","family":"Navidifar","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Shoushtar Faculty of Medical Sciences Shoushtar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Dadgar\u2010Zankbar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arezoo","family":"Asadi","sequence":"additional","affiliation":[{"name":"Endocrine Research Center, Institute of Endocrinology and Metabolism Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Ghamari","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, School of Public Health Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Najafi","sequence":"additional","affiliation":[{"name":"Faculty of Sports and Exercise Science University Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2016-3512","authenticated-orcid":false,"given":"Shabnam Zeighamy","family":"Alamdary","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6913-5769","authenticated-orcid":false,"given":"Roghayeh","family":"Afifirad","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-0001","authenticated-orcid":false,"given":"Roya","family":"Ghanavati","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Behbahan Faculty of Medical Sciences Behbahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atieh","family":"Darbandi","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Research Center Shahed University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2021.10.004"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13099-021-00477-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15205019"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-018-0542-5"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5284754"},{"issue":"4","key":"e_1_2_12_7_1","first-page":"293","article-title":"Systematic Review: Gut Microbiota in Fecal Samples and Detection of Colorectal Neoplasms","volume":"9","author":"Amitay E. 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