{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:20:55Z","timestamp":1787732455769,"version":"build-2784847793"},"reference-count":109,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Pteropus medius<\/jats:italic>\n                    is a major reservoir of Nipah virus (NiV), a zoonotic pathogen responsible for recurrent fatal encephalitis outbreaks in Bangladesh. Human infections are primarily associated with consuming raw date palm sap contaminated with bat excreta. Beyond viral spillover, growing evidence suggests that bat\u2010associated microbiota and guano are potential reservoirs of antimicrobial resistance (AMR), contributing to the environmental dissemination of resistant bacteria and resistance genes. This narrative literature review examined the relationship among NiV spillover, bat microbiota, and AMR within a One Health framework. A structured literature search was conducted using PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar to identify relevant peer\u2010reviewed studies published between 2006 and 2025. The reviewed evidence indicates that\n                    <jats:italic>Pteropus medius<\/jats:italic>\n                    populations harbor clinically important resistant bacteria, including ESBL\u2010(Extended\u2010Spectrum Beta\u2010Lactamase) producing\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Salmonella<\/jats:italic>\n                    spp., and methicillin\u2010resistant\n                    <jats:italic>Staphylococcus<\/jats:italic>\n                    spp. In addition, recent studies indicate that bat roosts near agricultural lands, wastewater discharge sites, and peri\u2010urban settlements may facilitate bidirectional exchange of ARGs among wildlife, livestock, and humans. Habitat fragmentation, wastewater contamination, urbanization, agricultural intensification, and increased human\u2013wildlife interactions were identified as major drivers facilitating both NiV spillover and AMR dissemination. Overall, the literature demonstrates a significant ecological association among anthropogenic environmental disturbance, zoonotic spillover risk, and the emergence of antimicrobial resistance in bat\u2010associated systems. These findings highlight the importance of integrated One Health surveillance and environmental management strategies to mitigate future zoonotic and AMR threats in Bangladesh.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70362","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:50:48Z","timestamp":1782967848000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One Health Insights From\n                    <i>Pteropus medius<\/i>\n                    : Nipah Virus Spillover, Microbiota, and Antimicrobial Resistance"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5617-644X","authenticated-orcid":false,"given":"Punam","family":"Chowdhury","sequence":"first","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology Chattogram Veterinary and Animal Sciences University (CVASU)  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3459-9712","authenticated-orcid":false,"given":"Shah Md Tanvir","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology Chattogram Veterinary and Animal Sciences University (CVASU)  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sajal","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology Gopalganj Science and Technology University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-6720","authenticated-orcid":false,"given":"Md. Shohel Al","family":"Faruk","sequence":"additional","affiliation":[{"name":"Department of Physiology, Biochemistry and Pharmacology Chattogram Veterinary and Animal Sciences University (CVASU)  Chattogram Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,1]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocontrol.2017.07.009"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.7589\/0090\u20103558\u201045.4.952"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2025.1199\u20101213"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201019738\u20105"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102180\u201012\u2010279"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20100998.2008.02387.x"},{"key":"e_1_2_17_8_1","first-page":"e124","volume-title":"The Lancet Planetary Health","author":"Arnold K. 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