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This study aimed to critically evaluate the current evidence on how phytochemicals modulate gut microbiota and GBA signaling to influence the progression of AD and PD. A systematic literature search was conducted using major scientific databases, and preclinical studies investigating microbiota\u2010mediated mechanisms of phytochemicals were synthesized according to predefined inclusion criteria. The available evidence demonstrates that phytochemicals consistently remodel the gut microbiota by increasing beneficial taxa such as\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    , and short\u2010chain fatty acid (SCFA)\u2010producing bacteria while suppressing pro\u2010inflammatory Gram\u2010negative microorganisms. These microbial alterations were associated with reduced lipopolysaccharide (LPS) production, inhibition of TLR4\/NF\u2010\u03baB and NLRP3 inflammasome signaling, enhancement of brain\u2010derived neurotrophic factor (BDNF) activity, restoration of intestinal barrier integrity, attenuation of oxidative stress, and activation of autophagy\u2010related pathways, including PI3K\/AKT\/mTOR and AMPK\/mTOR, leading to reduced amyloid\u2010\u03b2, tau, and \u03b1\u2010synuclein pathology. A major contribution of this review is the integration of current evidence demonstrating the bidirectional crosstalk between phytochemicals and the gut microbiota as a central mechanism regulating GBA signaling in AD and PD. Available evidence suggests that phytochemical\u2010mediated modulation of the gut microbiota represents a promising therapeutic strategy for slowing disease progression in AD and PD. However, further mechanistic investigations and well\u2010designed clinical trials are required to validate these findings and facilitate their translation into clinical practice.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70374","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T09:11:12Z","timestamp":1786612272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microbiome\u2010Phytochemical Crosstalk Along the Gut\u2010Brain Axis in Alzheimer and Parkinson's Disease"],"prefix":"10.1002","volume":"15","author":[{"given":"Md.","family":"Emon","sequence":"first","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3235-9117","authenticated-orcid":false,"given":"Md. Mizanur","family":"Rahaman","sequence":"additional","affiliation":[{"name":"Biomedical Sciences and Molecular Biology, College of Medicine and Dentistry, James Cook University Townsville Queensland Australia"},{"name":"Australian Institute of Tropical Health and Medicine, James Cook University Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0102-0970","authenticated-orcid":false,"given":"Dhrubo","family":"Sarder","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1587-2838","authenticated-orcid":false,"given":"Md.","family":"Shadin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamima Akter","family":"Neela","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Gopalganj Science and Technology University Gopalganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-7382","authenticated-orcid":false,"given":"Phurpa","family":"Wangchuk","sequence":"additional","affiliation":[{"name":"College of Science and Engineering, James Cook University Cairns Queensland Australia"},{"name":"Australian Institute of Tropical Health and Medicine James Cook University Cairns Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2685-8377","authenticated-orcid":false,"given":"Subir","family":"Sarker","sequence":"additional","affiliation":[{"name":"Biomedical Sciences and Molecular Biology, College of Medicine and Dentistry, James Cook University Townsville Queensland Australia"},{"name":"Australian Institute of Tropical Health and Medicine, James Cook University Townsville Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2024.105681"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86514-6"},{"key":"e_1_2_12_4_1","first-page":"1113","article-title":"Potential Protective Roles of Phytochemicals on Glutamate\u2010Induced Neurotoxicity: A Review","volume":"23","author":"Afshari A. 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