{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:20:58Z","timestamp":1787732458138,"version":"build-2784847793"},"reference-count":94,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    is a major multidrug\u2010resistant nosocomial pathogen, and new antimicrobial strategies are urgently needed. Green\u2010synthesized silver nanoparticles (AgNPs) have emerged as promising candidates because of their broad antibacterial activity and potentially improved biocompatibility. This systematic review evaluated the antibacterial effects of pure, plant\u2010mediated AgNPs against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    isolates. PubMed, Scopus, and Web of Science were searched from database inception to October 5, 2025 according to PRISMA guidelines. Eligible studies were original English\u2010language reports assessing pure green\u2010synthesized AgNPs against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    . Sixty\u2010three studies met the inclusion criteria. Green AgNPs were generally active against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    and more often showed stronger effects than the corresponding plant extracts. The most commonly proposed mechanisms were reactive oxygen species generation, membrane and cell\u2013wall disruption, increased permeability, and damage to proteins, lipids, or DNA. Biofilm data were limited but suggested promising inhibitory potential. Toxicity findings were mixed, ranging from good biocompatibility to cytotoxicity in sensitive cell models. Plant\u2010mediated AgNPs show credible antibacterial potential against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    , but standardized synthesis, rigorous characterization, biofilm\u2010focused testing, and in vivo safety studies are still needed before clinical translation.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70378","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:26:42Z","timestamp":1787124402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green\u2010Synthesized Silver Nanoparticles Against\n                    <i>Acinetobacter baumannii<\/i>\n                    : A Systematic Review of Antibacterial Activity, Mechanisms of Action, Toxicity, and Antibiofilm 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