{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:03:18Z","timestamp":1790326998424,"version":"4.1.0"},"reference-count":85,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["MicrobiologyOpen"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bacteria\u2010derived carotenoids have attracted increasing attention as natural bioactive compounds with potential pharmaceutical applications, particularly in cancer therapy. However, the chemical composition and anticancer mechanisms of carotenoids from\n                    <jats:italic>Micrococcus terreus<\/jats:italic>\n                    remain largely unexplored. This study aimed to characterize the carotenoid extract from the locally isolated\n                    <jats:italic>M. terreus<\/jats:italic>\n                    SK34 strain (GenBank: PX765938) and to investigate its anticancer activity and underlying mechanisms using integrated in vitro and in silico approaches. Under nonoptimized culture conditions, strain SK34 produced 128\u2009mg\/L of carotenoid\u2010rich pigment extract. LC\u2010Q\u2010TOF\u2010MS analysis identified eight carotenoids, including phytoene, \u03b2\u2010carotene, astaxanthin, zeaxanthin, \u03b2\u2010cryptoxanthin, \u03b1\u2010carotene, lycopene, and sarcinaxanthin. The extract exerted selective cytotoxicity against different cancer cell lines (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u200961.91\u2013243.76\u2009\u03bcg\/mL), particularly the neuroblastoma (SH\u2010SY5Y) cancer cell line, while showing minimal cytotoxicity toward normal human dermal fibroblasts. Gene expression analysis demonstrated the significant upregulation of proapoptotic genes (p53, BAX, CASP3, CASP8, and CASP9) in the SH\u2010SY5Y cell line, together with the downregulation of antiapoptotic genes (BCL\u20102 and AKT1), whereas autophagy\u2010related genes were not significantly affected. ELISA and flow cytometry analyses further confirmed apoptosis in the SH\u2010SY5Y cell line. Molecular docking analyses revealed that \u03b2\u2010carotene, astaxanthin, and zeaxanthin exhibited strong binding affinities toward apoptosis\u2010related proteins, supporting the experimental findings. This study provides the first comprehensive characterization of carotenoids from\n                    <jats:italic>M. terreus<\/jats:italic>\n                    SK34 and highlights their potential as selective apoptosis\u2010inducing agents for future anticancer therapy.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70382","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:16:13Z","timestamp":1790324173000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Carotenoid\u2010Rich Pigment Extract From\n                    <i>Micrococcus terreus<\/i>\n                    SK34 Induces Apoptosis in SH\u2010SY5Y Neuroblastoma Cells: Integrated Metabolomic, Molecular Docking, and Experimental Validation"],"prefix":"10.1002","volume":"15","author":[{"given":"Sinem Ilayda","family":"Karaagac","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"Albayrak","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5573-1360","authenticated-orcid":false,"given":"Azizeh","family":"ShadiDizaji","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology, Faculty of Agriculture Ataturk University Erzurum T\u00fcrkiye"},{"name":"Vaccine Development Application and Research Center Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Enes","family":"Kiziler","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvan","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli Pinar","family":"Arslan","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services Bingol University Bingol T\u00fcrkiye"},{"name":"Department of Basic Sciences, Faculty of Dentistry Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9350-9628","authenticated-orcid":false,"given":"Mesut","family":"Taskin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Faculty of Science Ataturk University Erzurum T\u00fcrkiye"},{"name":"Vaccine Development Application and Research Center Ataturk University Erzurum T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568-025-01825-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/bbb.70099","article-title":"Water\u2010Soluble Exopolysaccharide of Niallia circulans BP13 Exhibits Antioxidant, Wound Healing, Skin Anti\u2010Aging and Anticancer Activities","volume":"20","author":"Albayrak S.","year":"2026","journal-title":"Biofuels, Bioproducts and Biorefining"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bmc.2016.10.040","article-title":"A Novel Adamantane Thiadiazole Derivative Induces Mitochondria\u2010Mediated Apoptosis in Lung Carcinoma Cell Line","volume":"25","author":"Ali A. G.","year":"2017","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"1","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12934-025-02847-1","article-title":"Advances in Biomanufacturing and Recent Biological Applications of the Fundamental Bacterial Carotenoids: A Comprehensive Review","volume":"24","author":"Al\u2010Monofy K. B.","year":"2025","journal-title":"Microbial Cell Factories"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33665"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1096\/fasebj.10.2.8641556","article-title":"Genetics and Molecular Biology of Carotenoid Pigment Biosynthesis","volume":"10","author":"Armstrong G. A.","year":"1996","journal-title":"FASEB Journal"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s12272-025-01541-5","article-title":"A Review on Bacteria\u2010Derived Antioxidant Metabolites: Their Production, Purification, Characterization, Potential Applications, and Limitations","volume":"48","author":"Arslan N. P.","year":"2025","journal-title":"Archives of Pharmacal Research"},{"issue":"9","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1080\/10408398.2023.2298770","article-title":"Fungi\u2010Derived Natural Antioxidants","volume":"65","author":"Arslan N. P.","year":"2025","journal-title":"Critical Reviews in Food Science and Nutrition"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00294-014-0454-x","article-title":"Biological Roles of Fungal Carotenoids","volume":"61","author":"Avalos J.","year":"2015","journal-title":"Current Genetics"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13091060"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10030131"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28382"},{"issue":"2","key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1017\/S0954422421000147","article-title":"Mechanistic Aspects of Carotenoid Health Benefits\u2014Where Are We Now?","volume":"34","author":"Bohn T.","year":"2021","journal-title":"Nutrition Research Reviews"},{"key":"e_1_2_10_15_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.842376","article-title":"Cancer and Apoptosis: The Apoptotic Activity of Plant and Marine Natural Products and Their Potential as Targeted Cancer Therapeutics","volume":"13","author":"Chaudhry G. S.","year":"2022","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_10_16_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105089","article-title":"Natural Metabolites With Antioxidant Activity From Micro\u2010 and Macro\u2010Algae","volume":"62","author":"Esim N.","year":"2024","journal-title":"Food Bioscience"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200713384"},{"issue":"3","key":"e_1_2_10_18_1","first-page":"165","article-title":"Caspase Control: Protagonists of Cancer Cell Apoptosis","volume":"34","author":"Fiandalo M. V.","year":"2012","journal-title":"Experimental Oncology"},{"issue":"2","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202201098","article-title":"Cytotoxic Activity of Herbal Medicines as Assessed In Vitro: A Review","volume":"20","author":"Gavanji S.","year":"2023","journal-title":"Chemistry & Biodiversity"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-34419-x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8793-1_3"},{"issue":"9","key":"e_1_2_10_23_1","first-page":"169","article-title":"Identification and Characterization of Extracellular Red Pigment Producing Bacteria Isolated From Soil","volume":"3","author":"Goswami B.","year":"2014","journal-title":"International Journal of Current Microbiology and Applied Sciences"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20080524"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-026-02261-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12896-024-00899-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27175436"},{"key":"e_1_2_10_28_1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.procbio.2023.11.033","article-title":"Synergistic Effects of Carotenoids: Therapeutic Benefits on Human Health","volume":"136","author":"Islam F.","year":"2024","journal-title":"Process Biochemistry"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1528230"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112256","article-title":"Ganoderma Lucidum Spore Oil Induces Apoptosis of Breast Cancer Cells In Vitro and In Vivo by Activating Caspase\u20103 and Caspase\u20109","volume":"247","author":"Jiao C.","year":"2020","journal-title":"Journal of Ethnopharmacology"},{"key":"e_1_2_10_31_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2020.104149","article-title":"Diapolycopenedioic\u2010Acid\u2010Diglucosyl Ester and Keto\u2010Myxocoxanthin Glucoside Ester: Novel Carotenoids Derived From Exiguobacterium acetylicum S01 and Evaluation of Their Anticancer and Anti\u2010Inflammatory Activities","volume":"103","author":"Jinendiran S.","year":"2020","journal-title":"Bioorganic Chemistry"},{"issue":"4","key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00210-022-02214-6","article-title":"Beta\u2010Carotene Exerted Anti\u2010Proliferative and Apoptotic Effect on Malignant Mesothelioma Cells","volume":"395","author":"Kacar S.","year":"2022","journal-title":"Naunyn\u2010Schmiedeberg's Archives of Pharmacology"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-023-03751-1"},{"issue":"1","key":"e_1_2_10_34_1","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ae2409","article-title":"Enhancing Wound Healing: Incorporating Carotenoid Pigments From Kocuria sp. Bacteria in Alginate\/Chitosan\/PVA Dressing","volume":"21","author":"Karimian Dorhoni M.","year":"2026","journal-title":"Biomedical Materials"},{"issue":"5","key":"e_1_2_10_35_1","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/md18050266","article-title":"Astaxanthin Modulates Apoptotic Molecules to Induce Death of SKBR3 Breast Cancer Cells","volume":"18","author":"Kim M. S.","year":"2020","journal-title":"Marine Drugs"},{"issue":"1","key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00203-021-02742-4","article-title":"Farnesol and Tyrosol: Novel Inducers for Microbial Production of Carotenoids and Prodigiosin","volume":"204","author":"Kiziler M. E.","year":"2022","journal-title":"Archives of Microbiology"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/app15073506"},{"issue":"1","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.31557\/APJCP.2023.24.1.257","article-title":"Isolation, Culture and Morphological Assessment of Primary Cell Lines From Human Primary Oral Squamous Cell Carcinoma Using Explant Technique","volume":"24","author":"Ladke V.","year":"2023","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"7","key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.3390\/pharmaceutics17070829","article-title":"Enhanced Anticancer Potential of Pd (II)\u2010Thiosemicarbazone Complexes: Selectivity, Mechanisms, and 3D Models","volume":"17","author":"Lima M. A.","year":"2025","journal-title":"Pharmaceutics"},{"key":"e_1_2_10_40_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.abb.2015.02.018","article-title":"The Anti\u2010Cancer Effects of Carotenoids and Other Phytonutrients Resides in Their Combined Activity","volume":"572","author":"Linnewiel\u2010Hermoni K.","year":"2015","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"4","key":"e_1_2_10_41_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real\u2010Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak K. J.","year":"2001","journal-title":"Methods"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2021.2016366"},{"issue":"11","key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.2174\/0929867322666150209150639","article-title":"A Simple and Reliable Approach for Assessing Anticancer Activity In Vitro","volume":"22","author":"Lopez\u2010Lazaro M.","year":"2015","journal-title":"Current Medicinal Chemistry"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.5702\/massspectrometry.A0133"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1867959"},{"key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejbt.2021.05.004","article-title":"Production of Carotenoid Sarcinaxanthin by Kocuria palustris Isolated From Northeastern Brazil Caatinga Soil and Their Antioxidant and Photoprotective Activities","volume":"53","author":"Mendes\u2010Silva T. C. D.","year":"2021","journal-title":"Electronic Journal of Biotechnology"},{"issue":"11","key":"e_1_2_10_47_1","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1111\/bph.13625","article-title":"Carotenoids: Biochemistry, Pharmacology and Treatment","volume":"174","author":"Milani A.","year":"2017","journal-title":"British Journal of Pharmacology"},{"issue":"4","key":"e_1_2_10_48_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4103\/0972-0464.142394","article-title":"Antioxidant, Antibacterial, and Ultraviolet\u2010Protective Properties of Carotenoids Isolated From Micrococcus spp","volume":"36","author":"Mohana D.","year":"2013","journal-title":"Radiation Protection and Environment"},{"issue":"1","key":"e_1_2_10_49_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/07357907.2024.2445528","article-title":"A Comprehensive Insight into Apoptosis: Molecular Mechanisms, Signaling Pathways, and Modulating Therapeutics","volume":"43","author":"Mosadegh M.","year":"2025","journal-title":"Cancer Investigation"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-9557-5"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13221838"},{"issue":"3","key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/bab.2170","article-title":"Bacterial Pigments: A Colorful Palette Reservoir for Biotechnological Applications","volume":"69","author":"Orlandi V. T.","year":"2022","journal-title":"Biotechnology and Applied Biochemistry"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551-016-0247-1"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12051030"},{"issue":"1","key":"e_1_2_10_55_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e41400","article-title":"Enhanced UV\u2010B Photoprotection Activity of Carotenoids From the Novel Arthrobacter sp. Strain LAPM80 Isolated From King George Island, Antarctica","volume":"11","author":"Paredes Contreras B. V.","year":"2025","journal-title":"Heliyon"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biortech.2022.126910","article-title":"Algae as an Emerging Source of Bioactive Pigments","volume":"351","author":"Patel A. K.","year":"2022","journal-title":"Bioresource Technology"},{"issue":"4","key":"e_1_2_10_57_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.18632\/aging.100934","article-title":"Apoptosis as Anticancer Mechanism: Function and Dysfunction of Its Modulators and Targeted Therapeutic Strategies","volume":"8","author":"Pistritto G.","year":"2016","journal-title":"Aging"},{"key":"e_1_2_10_58_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.biortech.2012.09.036","article-title":"Biosorption of Lead and Copper by Heavy\u2010Metal Tolerant Micrococcus luteus DE2008","volume":"126","author":"Puyen Z. M.","year":"2012","journal-title":"Bioresource Technology"},{"key":"e_1_2_10_59_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.103867","article-title":"Bacteria as an Alternate Biofactory for Carotenoid Production: A Review of Its Applications, Opportunities and Challenges","volume":"67","author":"Ram S.","year":"2020","journal-title":"Journal of Functional Foods"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.17179\/excli2017-218"},{"issue":"4","key":"e_1_2_10_61_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1177\/0394632016673846","article-title":"Some Biological Activities of Pigments Extracted From Micrococcus roseus (PTCC 1411) and Rhodotorula glutinis (PTCC 5257)","volume":"29","author":"Rostami H.","year":"2016","journal-title":"International Journal of Immunopathology and Pharmacology"},{"issue":"10","key":"e_1_2_10_62_1","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1007\/s12035-023-03433-5","article-title":"A Review on Caspases: Key Regulators of Biological Activities and Apoptosis","volume":"60","author":"Sahoo G.","year":"2023","journal-title":"Molecular Neurobiology"},{"issue":"5","key":"e_1_2_10_63_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10295-018-2104-7","article-title":"Microbial Platforms to Produce Commercially Vital Carotenoids at Industrial Scale: An Updated Review of Critical Issues","volume":"46","author":"Saini R. K.","year":"2019","journal-title":"Journal of Industrial Microbiology and Biotechnology"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/fermentation10100502"},{"issue":"7","key":"e_1_2_10_65_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4103\/2221-1691.350176","article-title":"Anticancer Drug Screening of Natural Products: In Vitro: Cytotoxicity Assays, Techniques, and Challenges","volume":"12","author":"Setiawati A.","year":"2022","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11081171"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28186665"},{"issue":"8","key":"e_1_2_10_68_1","doi-asserted-by":"crossref","first-page":"077","DOI":"10.7324\/JAPS.2021.110811","article-title":"Yellow Pigment From a Novel Bacteria, Micrococcus terreus, Activates Caspases and Leads to Apoptosis of Cervical and Liver Cancer Cell Lines","volume":"11","author":"Shukla M.","year":"2021","journal-title":"Journal of Applied Pharmaceutical Science"},{"issue":"5","key":"e_1_2_10_69_1","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1128\/aem.51.5.963-968.1986","article-title":"Degradation of Pyridine by Micrococcus luteus Isolated From Soil","volume":"51","author":"Sims G. K.","year":"1986","journal-title":"Applied and Environmental Microbiology"},{"issue":"3","key":"e_1_2_10_70_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11912-022-01199-y","article-title":"Targeting Apoptosis in Cancer","volume":"24","author":"Singh P.","year":"2022","journal-title":"Current Oncology Reports"},{"issue":"1","key":"e_1_2_10_71_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of Protein Using Bicinchoninic Acid","volume":"150","author":"Smith P. K.","year":"1985","journal-title":"Analytical Biochemistry"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2021.1955285"},{"issue":"9","key":"e_1_2_10_73_1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.3390\/foods13091321","article-title":"The Efficacy of Dietary Intake, Supplementation, and Blood Concentrations of Carotenoids in Cancer Prevention: Insights From an Umbrella Meta\u2010Analysis","volume":"13","author":"Sui J.","year":"2024","journal-title":"Foods"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-025-04261-1"},{"issue":"2","key":"e_1_2_10_75_1","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/pbi.14522","article-title":"Natural Pigments Derived From Plants and Microorganisms: Classification, Biosynthesis, and Applications","volume":"23","author":"Tang Q.","year":"2025","journal-title":"Plant Biotechnology Journal"},{"issue":"22","key":"e_1_2_10_76_1","doi-asserted-by":"crossref","first-page":"4638","DOI":"10.1080\/14786419.2019.1698574","article-title":"Antiproliferative Activity of Carotenoid Pigments Produced by Extremophile Bacteria","volume":"35","author":"Tapia C.","year":"2021","journal-title":"Natural Product Research"},{"issue":"8","key":"e_1_2_10_77_1","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jsfa.4329","article-title":"Production of Carotenoids by Rhodotorula glutinis MT\u20105 in Submerged Fermentation Using the Extract From Waste Loquat Kernels as Substrate","volume":"91","author":"Taskin M.","year":"2011","journal-title":"Journal of the Science of Food and Agriculture"},{"issue":"4","key":"e_1_2_10_78_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00217-011-1561-2","article-title":"Use of Waste Chicken Feathers as Peptone for Production of Carotenoids in Submerged Culture of Rhodotorula glutinis MT\u20105","volume":"233","author":"Taskin M.","year":"2011","journal-title":"European Food Research and Technology"},{"issue":"3","key":"e_1_2_10_79_1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijcas.2013.08.008","article-title":"Antibacterial Activity of Pigment Produced From Micrococcus luteus KF532949","volume":"4","author":"Umadevi K.","year":"2013","journal-title":"International Journal of Chemical and Analytical Science"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-96788-9"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12183469"},{"key":"e_1_2_10_82_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jbiotec.2026.01.009","article-title":"Streptomyces bottropensis SY8\u2010derived Eumelanin Exhibits Skin Wound Healing Activity and Prevents H2O2 or UV\u2010Induced Skin Aging","volume":"411","author":"Yildirim S.","year":"2026","journal-title":"Journal of Biotechnology"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081493"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113466"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijs.0.013235-0"},{"issue":"1","key":"e_1_2_10_86_1","first-page":"29","article-title":"Molecular Cloning and Anti\u2010Cancer Activity of Carotenoid Pigments Isolated From Micrococcus spp. and Rhodotorula spp","volume":"32","author":"Zohari M.","year":"2021","journal-title":"Journal of Sciences, Islamic Republic of Iran"}],"container-title":["MicrobiologyOpen"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.70382","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mbo3.70382","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mbo3.70382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:16:21Z","timestamp":1790324181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mbo3.70382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":85,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/mbo3.70382"],"URL":"https:\/\/doi.org\/10.1002\/mbo3.70382","archive":["Portico"],"relation":{},"ISSN":["2045-8827","2045-8827"],"issn-type":[{"value":"2045-8827","type":"print"},{"value":"2045-8827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2026-05-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70382"}}