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A promising approach to address this problem involves the use of combination therapies, in which plant\u2010derived natural products represent an important reservoir of bioactive compounds with the potential to act as effective adjuvants, restoring or enhancing antibiotic efficacy. In this study, the ethanolic extract of\n                    <jats:italic>Mouriri elliptica<\/jats:italic>\n                    (EME) leaves was investigated for its antimicrobial and synergistic potential. EME showed moderate inhibitory activity against both standard and MDR strains, with the most significant effect against\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    (MIC 78.1\u2013312.5\u2009\u00b5g\/mL). Synergistic interactions were observed with conventional antibiotics, particularly ciprofloxacin against\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    , reducing MIC values up to fifteen\u2010fold, and with ampicillin against\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . The extract also inhibited biofilm formation, with 68% inhibition for\n                    <jats:italic>E. coli<\/jats:italic>\n                    at 500\u2009\u00b5g\/mL and 72.04% for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    at 250\u2009\u00b5g\/mL, with atomic force microscopy images corroborating these findings. LC\u2010MS profiling identified 41 compounds, including chlorogenic acid derivatives, flavonoids, ellagic acid derivatives, and triterpenes. Acute toxicity evaluation in mice at 2000\u2009mg\/kg revealed no adverse effects. Collectively, these findings support the potential of\n                    <jats:italic>M. elliptica<\/jats:italic>\n                    as a natural antibacterial adjuvant for enhancing the effectiveness of selected antibiotics against MDR pathogens, warranting further chemical, mechanistic, and in vivo investigation.\n                  <\/jats:p>","DOI":"10.1002\/mbo3.70392","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:11:47Z","timestamp":1789013507000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant Antibacterial Effects of\n                    <i>Mouriri Elliptica<\/i>\n                    Against Clinical Multidrug Resistant Gram\u2010Negative Bacterial Strains"],"prefix":"10.1002","volume":"15","author":[{"given":"Talita Vilalva","family":"Freire","sequence":"first","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Research on Bioactive Natural Products (PRONABio), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina de Freitas","family":"Marques","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Institute of Biology (INBIO) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria dos Santos","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Research on Bioactive Natural Products (PRONABio), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iluska Senna Bonf\u00e1","family":"Moslaves","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Faculty of Pharmaceutical Sciences (FACFAN) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica Cristina","family":"Toffoli\u2010Kadri","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Faculty of Pharmaceutical Sciences (FACFAN) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Feliciano Camargo da","family":"Silva","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Electrochemistry of Advanced Materials (LEMA), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-1312","authenticated-orcid":false,"given":"Martha Janete","family":"Giz","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Electrochemistry of Advanced Materials (LEMA), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3977-3556","authenticated-orcid":false,"given":"Patr\u00edcia de Oliveira","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Research on Bioactive Natural Products (PRONABio), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Camila","family":"Micheletti","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Research on Bioactive Natural Products (PRONABio), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-9300","authenticated-orcid":false,"given":"N\u00eddia Cristiane","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso do Sul, Laboratory of Research on Bioactive Natural Products (PRONABio), Institute of Chemistry (INQUI) Campo Grande Mato Grosso do Sul Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2016.08.160"},{"key":"e_1_2_12_3_1","volume-title":"Microbiologia cl\u00ednica para o controle de infec\u00e7\u00e3o relacionada \u00e0 assist\u00eancia \u00e0 sa\u00fade: M\u00f3dulo 10 \u2013 Detec\u00e7\u00e3o dos principais mecanismos de resist\u00eancia bacteriana aos antimicrobianos pelo laborat\u00f3rio de microbiologia cl\u00ednica (10 vols., 160 p.)","author":"ANVISA (Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria)","year":"2020"},{"key":"e_1_2_12_4_1","first-page":"229","article-title":"In Vitro Culture of Mouriri elliptica (Mart.) 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