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Abundant evidence suggests that gastrointestinal microbiota dysbiosis plays an important role in the development of gastrointestinal cancers by producing proinflammatory and immunosuppressive signals. This review examines the role of microbiome dysbiosis in the pathogenesis of gastrointestinal malignancies. The composition of the microbiota varies greatly among individuals and depends on various factors such as age, diet, lifestyle, genetics, medications, and environmental factors. Given this diversity, a comprehensive characterization of the gastrointestinal microbiota is crucial to elucidate its role in carcinogenesis. Therefore, investigating the microbial composition of the host gastrointestinal tract can provide important information about the status of gastrointestinal cancers.<\/jats:p>","DOI":"10.1002\/mbo3.70404","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:50:10Z","timestamp":1788951010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastrointestinal Microbiome Dysbiosis in Cancer Development: Mechanisms and Biomarker Potential"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-1089","authenticated-orcid":false,"given":"Negar","family":"Asgari","sequence":"first","affiliation":[{"name":"Institute of Regenerative Medicine and Biotherapy Universit\u00e9 de Montpellier, CHU de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9179-391X","authenticated-orcid":false,"given":"Mehrasa","family":"Asghari","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center Biomedical Research Institute, Golestan University of Medical Sciences Gorgan Iran"},{"name":"Department of Molecular Medicine Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8207-6572","authenticated-orcid":false,"given":"Touraj","family":"Farazmandfar","sequence":"additional","affiliation":[{"name":"Medical Cellular and Molecular Research Center Biomedical Research Institute, Golestan University of Medical Sciences Gorgan Iran"},{"name":"Department of Molecular Medicine Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.01055-22"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.745325"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1130562"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00883-8"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.046"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16289-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1481"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2071011"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.01.007"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-021-03729-w"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26146958"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00608"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-024-00577-x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01654-2"},{"key":"e_1_2_14_16_1","first-page":"178","article-title":"The Intestinal Microbiome in Human Health and Disease","volume":"131","author":"Dupont H. 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